ReviewTrends in pharmacological sciences2020
Targeting Bacterial Genomes for Natural Product Discovery.
Review in Trends in pharmacological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed.
- Transposon mutagenesis in bacterial natural product discovery.Essays in biochemistry · 2026Review
- Computational Screening of Selected Phytochemicals Against Levofloxacin and Metronidazole-Resistant IndonesianMicroorganisms · 2026Article
- Genome Mining-Driven Isolation of New Gromomycins and Insights into Their Mode of Action.ACS chemical biology · 2026Article
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.Natural product reports · 2026Review
- DAP-seq Reveals Cluster-Situated Regulator Control of NumerousbioRxiv : the preprint server for biology · 2026Article
- Hidden in the Pangenome? Machine Learning-Driven Discovery of Antimicrobial Potential inBioinformatics and biology insights · 2026Article
- Unexplored biosynthetic gene clusters in bacteria isolated from Brazilian stingless bee honey with activity against multidrug-resistant pathogens.Current research in microbial sciences · 2026Article
- Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Anticancer compounds from Streptomyces: insights from metagenomics and mechanistic perspective.Folia microbiologica · 2025Review
- Research Progress on the Regulation and Developmental Utilization of Bioactive Metabolites Synthesis inJournal of fungi (Basel, Switzerland) · 2025Review
- Phosphorylation of peptides by a kinase domain in cyanobactin pathways.Nature communications · 2025Article
- iCASRED, a scarless DNA editing tool inSynthetic and systems biotechnology · 2025Article
- Genomic Insights intoInternational journal of molecular sciences · 2025Article
- Article
- Genome mining reveals the biosynthetic potential of a novel Lysinibacillus zambalensis sp. nov., isolated from a hyperalkaline spring.Archives of microbiology · 2025Article
- PPtase-activated production of borrelidin from extremophilic actinobacteria against multidrug-resistant cotton pathogen Verticillium dahliae.The Journal of antibiotics · 2025Article
- Article
- Novel Gene Clusters for Secondary Metabolite Synthesis in Mesophotic Sponge-Associated Bacteria.Microbial biotechnology · 2025Article
- The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes.Microbial cell factories · 2024Article
- Genomic Comparisons Revealed the Key Genotypes ofBioengineering (Basel, Switzerland) · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bacterial natural products (NPs) and their analogs constitute more than half of the new small molecule drugs developed over the past few decades. Despite this success, interest in natural products from major pharmaceutical companies has decreased even as genomics has uncovered the large number of biosynthetic gene clusters (BGCs) that encode for novel natural products. To date, there is still a lack of universal strategies and enabling technologies to discover natural products at scale and speed. This review highlights several of the opportunities provided by genome sequencing and bioinformatics, challenges associated with translating genomes into natural products, and examples of successful strain prioritization and BGC activation strategies that have been used in the genomic era for natural product discovery from cultivatable bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.