ArticleJournal of the International Neuropsychological Society : JINS2020
The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.
Article in Journal of the International Neuropsychological Society : JINS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- The Association Between Five Factor Model Personality Traits and Verbal and Numeric Reasoning.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Pooled it
- Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis.Biological psychiatry · 2022Pooled it
- Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Using objective and subjective measures of mind wandering to predict progression to development of cognitive impairment and test associations with Alzheimer disease biomarkers.Journal of clinical and experimental neuropsychology · 2025Article
- Personality nuances and cognition: A multi-cohort and multi-method approach.Journal of psychiatric research · 2025Article
- Personality, Aging, and Alzheimer's Disease: Implications for Psychoneuroimmunology and Personalized Medicine.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.Neurology · 2024Observational
- High-frequency assessment of mood, personality, and cognition in healthy younger, healthy older and adults with cognitive impairment.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- Neuroticism and white matter hyperintensities.Journal of psychiatric research · 2023Article
- The association between personality and plasma biomarkers of astrogliosis and neuronal injury.Neurobiology of aging · 2023Article
- Association Between Neuroticism and Dementia on Healthcare Use: A Multi-Level Analysis Across 27 Countries from The Survey of Health, Ageing and Retirement in Europe (SHARE).Journal of Alzheimer's disease : JAD · 2023Article
- Personality pathology predicts increased informant-reported, but not performance-based, cognitive decline: Findings from two samples.Personality disorders · 2022Article
- Facets of Personality and Risk of Cognitive Impairment: Longitudinal Findings in a Rural Community from Sardinia.Journal of Alzheimer's disease : JAD · 2022Article
- Subjective Cognitive Decline: Is a Resilient Personality Protective Against Progression to Objective Cognitive Impairment? Findings from Two Community-Based Cohort Studies.Journal of Alzheimer's disease : JAD · 2022Article
- Is neuroticism differentially associated with risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia?Journal of psychiatric research · 2021Article
- Is personality associated with dementia risk? A meta-analytic investigation.Ageing research reviews · 2021Review
- Personality and Dementia Risk in England and Australia.GeroPsych · 2020Article
- Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- The relationship between personality traits and Alzheimer's disease: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?
methodsBoth self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau.
resultsHigher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume.
conclusionsConscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.