Observational studyBMC nephrology2019
Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study.
Observational study in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Prevalence and Risk Factors Associated With ICU Mortality in Ethiopia: A Systemic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Prevalence, associated factors, and immediate outcomes of acute kidney injury in critically ill children in Tanzania.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Incidence, risk factors and outcomes of AKI among trauma patients in a tertiary hospital in south-east, Nigeria.BMC nephrology · 2025Article
- Incidence and predictors of acute kidney injury among traumatic brain injury patients in Northwest Ethiopia: a cohort study using survival analysis.BMC nephrology · 2025Article
- Article
- Long-term outcomes and associated factors among intensive care unit survivors in a low-income country: a multicenter prospective cohort study.BMC research notes · 2024Article
- Article
- Hospital-Acquired Acute Kidney Injury in Non-Critical Medical Patients in a Developing Country Tertiary Hospital: Incidence and Predictors.International journal of nephrology and renovascular disease · 2024Article
- Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis.BMC nephrology · 2023Article
- Acute kidney injury in diabetes mellitus: Epidemiology, diagnostic, and therapeutic concepts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Core competencies in critical care for general medical practitioners in South Africa: A Delphi study.The Southern African journal of critical care : the official journal of the Critical Care Society · 2023Article
- Scope and mortality of adult medical ICU patients in an Eastern Cape tertiary hospital.The Southern African journal of critical care : the official journal of the Critical Care Society · 2022Article
- Prevalence and Factors Associated with Acute Kidney Injury in Sub-Saharan African Adults: A Review of the Current Literature.International journal of nephrology · 2022Review
- Prediction of in-hospital mortality: An adaptive severity-of-illness score for a tertiary ICU in South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2022Article
- High risk of acute kidney injury in Malawian trauma patients: a prospective observational cohort study.BMC nephrology · 2021Observational
- Assessing association of preoperative estimated glomerular filtration rate with postoperative acute kidney injury in very elderly surgical patients.Renal failure · 2020Article
- The SAPS 3 score as a predictor of hospital mortality in a South African tertiary intensive care unit: A prospective cohort study.PloS one · 2020Observational
- Risk factors for development of acute kidney injury in hospitalised adults in Zimbabwe.PloS one · 2020Observational
- The incidence and outcomes of patients with acute kidney injury in a multidisciplinary intensive care unit in Durban, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a marked paucity of data concerning AKI in Sub-Saharan Africa, where there is a substantial burden of trauma and HIV.
methodsProspective data was collected on all patients admitted to a multi-disciplinary ICU in South Africa during 2017. Development of AKI (before or during ICU admission) was recorded and renal recovery 90 days after ICU discharge was determined.
resultsOf 849 admissions, the mean age was 42.5 years and mean SAPS 3 score was 48.1. Comorbidities included hypertension (30.5%), HIV (32.6%), diabetes (13.3%), CKD (7.8%) and active tuberculosis (6.2%). The most common reason for admission was trauma (26%). AKI developed in 497 (58.5%). Male gender, illness severity, length of stay, vasopressor drugs and sepsis were independently associated with AKI. AKI was associated with a higher in-hospital mortality rate of 31.8% vs 7.23% in those without AKI. Age, active tuberculosis, higher SAPS 3 score, mechanical ventilation, vasopressor support and sepsis were associated with an increased adjusted odds ratio for death. HIV was not independently associated with AKI or hospital mortality. CKD developed in 14 of 110 (12.7%) patients with stage 3 AKI; none were dialysis-dependent.
conclusionsIn this large prospective multidisciplinary ICU cohort of younger patients, AKI was common, often associated with trauma in addition to traditional risk factors and was associated with good functional renal recovery at 90 days in most survivors. Although the HIV prevalence was high and associated with higher mortality, this was related to the severity of illness and not to HIV status per se.
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