Evidence map›Paper›PMID 31822210›Full record

ArticleOpen biology2019

High-throughput dense reconstruction of cell lineages.

Isabel Espinosa-Medina, Jorge Garcia-Marques, Connie Cepko, Tzumin Lee

Abstract readConsensus Statement
In one paragraph

Article in Open biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Integrated Patterning Programs DuringAnnual review of neuroscience · 2021
    Article
  10. Deciphering neural heterogeneity through cell lineage tracing.Cellular and molecular life sciences : CMLS · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Isabel Espinosa-MedinaHoward Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Jorge Garcia-MarquesHoward Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Connie CepkoDepartment of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115, USA.
Tzumin LeeHoward Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent eruption of new tools that allow the reconstruction of lineages based on the phylogenetic analysis of DNA mutations induced during development. Combined with single-cell RNA sequencing, these tools promise to solve the lineage of complex model organisms at single-cell resolution. Here, we compile the conference consensus on the technological and computational challenges emerging from the use of the new strategies, as well as potential solutions.

Indexed as

Cell TrackingGene Expression ProfilingHigh-Throughput Nucleotide SequencingMolecular ImagingAnimalsCell LineageComputational BiologyCRISPR-Cas SystemsDNA Barcoding, TaxonomicHumansMutationPhylogenySingle-Cell AnalysisCRISPR/Cas9dynamic barcodinggenetic switchphylogenetic lineage reconstructionscRNA-Seq

Identifiers

PMID31822210
PMCPMC6936253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.