SynthesisPediatric research2020
Long-term neuropathological and/or neurobehavioral effects of antenatal corticosteroid therapy in animal models: a systematic review.
Synthesis in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The effect of antenatal corticosteroid use on offspring cardiovascular function: A systematic review.BJOG : an international journal of obstetrics and gynaecology · 2023Pooled it
- Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial.BMC medicine · 2024Trial
- Antenatal Corticosteroids: Short-Term Gains, Long-Term Questions-A Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Association between timing of antenatal corticosteroid and developmental outcomes in children born late preterm by high-risk pregnancies.BMC pregnancy and childbirth · 2026Article
- Associations between antenatal corticosteroids and neonatal morbidities in a prospective cohort: role of course, timing, and gestational age.Frontiers in pediatrics · 2026Article
- Neurodevelopmental outcomes in children and adults associated with antenatal corticosteroid exposure: a narrative review.European journal of pediatrics · 2025Review
- Long-Term Neurodevelopmental Outcomes After Antenatal Corticosteroid Therapy in Late Preterm Twins: A Nationwide Retrospective Cohort Study.Journal of Korean medical science · 2025Article
- Associations of Antenatal Corticosteroids With Neurodevelopment in Children Aged 27-30 Months: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Long-term outcomes of antenatal corticosteroids for preterm birth: An overview of systematic reviews.PLOS global public health · 2025Article
- [Effects of antenatal corticosteroids on outcomes of very premature infants and neurodevelopment during infancy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Value of preclinical systematic reviews and meta-analyses in pediatric research.Pediatric research · 2024Article
- Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis.Archives of gynecology and obstetrics · 2023Article
- Neurological implications of antenatal corticosteroids on late preterm and term infants: a scoping review.Pediatric research · 2022Article
- Little evidence for long-term harm from antenatal corticosteroids in a population-based very low birthweight young adult cohort.Paediatric and perinatal epidemiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntenatal corticosteroids (ACSs) are recommended to all women at risk for preterm delivery; currently, there is controversy about the subsequent long-term neurocognitive sequelae. This systematic review summarizes the long-term neurodevelopmental outcomes after ACS therapy in animal models.
methodsAn electronic search strategy incorporating MeSH and keywords was performed using all known literature databases and in accordance with PRISMA guidance (PROSPERO CRD42019119663).
resultsOf the 669 studies identified, eventually 64 were included. The majority of studies utilized dexamethasone at relative high dosages and primarily involved rodents. There was a high risk of bias, mostly due to lack of randomization, allocation concealment, and blinding. The main outcomes reported on was neuropathological, particularly glucocorticoid receptor expression and neuron densities, and neurobehavior. Overall there was an upregulation of glucocorticoid receptors with lower neuron densities and a dysregulation of the dopaminergic and serotonergic systems. This coincided with various adverse neurobehavioral outcomes.
conclusionsIn animal models, ACSs consistently lead to deleterious long-term neurocognitive effects. This may be due to the specific agents, i.e., dexamethasone, or the repetitive/higher total dosing used. ACS administration varied significantly between studies and there was a high risk of bias. Future research should be standardized in well-characterized models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.