Evidence map›Paper›PMID 31821855›Full record

ReviewMolecular and cellular endocrinology2020

Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures.

Gregory M Martin, Min Woo Sung, Show-Ling Shyng

Open access · greenAbstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Non-radioactive RbMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  5. Article
  6. Review
  7. Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  8. Article
  9. Review
  10. KFrontiers in endocrinology · 2023
    Review
  11. Review
  12. Article
  13. Functional Regulation of KFrontiers in pharmacology · 2022
    Review
  14. Article
  15. Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gregory M MartinDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA.
Min Woo SungDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA.
Show-Ling ShyngDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: shyngs@ohsu.edu.
Oregon Health & Science University · US

Funding

KATP channels and insulin secretionR01DK057699 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2001 to 2019
$6.1M
Structural Basis of KATP Channel GatingR01DK066485 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2006 to 2024
$5.8M
NIDDK NIH HHS R01 DK057699NIDDK NIH HHS R01 DK066485
6 · The paper itself

Abstract

ATP-sensitive potassium (K

Indexed as

AnimalsBlood GlucoseCarbamazepineCryoelectron MicroscopyDrug DesignHumansInsulinInsulin-Secreting CellsKATP ChannelsLigandsModels, MolecularMutationProtein ConformationBlood GlucoseCarbamazepineInsulinKATP ChannelsLigandsABC transporterCarbamazepineCongenital hyperinsulinismKir channelProtein assemblyProtein traffickingSulfonylurea receptorSulfonylureas

Identifiers

PMID31821855
PMCPMC6994177
OpenAlexW2994138288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.