ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2020
The Distribution and Prevalence of Macrophages in the Cochlea Following Cochlear Implantation in the Human: An Immunohistochemical Study Using Anti-Iba1 Antibody.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Hearing loss and dementia: radiologic and biomolecular basis of their shared characteristics. A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Comparative spatiotemporal dynamics of access resistance, polarization impedance, and nested bipolar impedance in standard and dexamethasone-eluting electrode arrays.Hearing research · 2026Article
- Robotic-Assisted Electrode Array Insertion Improves Stability of Acoustic Hearing Thresholds.The Laryngoscope · 2026Article
- Spatiotemporal Dynamics of Cochlear Implant Electrode Impedance in Standard and Dexamethasone-Eluting Electrode Arrays.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Sentinels or saboteurs, the Janus face of cochlear-resident macrophages in hearing loss: spatiotemporal distribution, pathophysiological functions, and translational potential.Journal of neuroinflammation · 2025Review
- Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae.Scientific reports · 2025Article
- Genetic polymorphisms in human CXJournal of neuroinflammation · 2025Article
- Electrode impedance dynamics in sequential cochlear implant users: insights into cochlear immunity.Frontiers in immunology · 2025Article
- Investigating cochlear cellular dynamics in neurofibromatosis type 2-associated schwannomatosis: a histopathological study.Frontiers in neurology · 2025Article
- Hearing Loss and Alzheimer Disease.Current topics in behavioral neurosciences · 2025Review
- Article
- Combinatorial Atoh1, Gfi1, Pou4f3, and Six1 gene transfer induces hair cell regeneration in the flat epithelium of mature guinea pigs.Hearing research · 2024Article
- Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation.Journal of neuroinflammation · 2023Article
- Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea.Brain sciences · 2023Article
- Archival Human Temporal Bone: Anatomical and Histopathological Studies of Cochlear Implantation.Journal of personalized medicine · 2023Review
- Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss.Frontiers in neuroscience · 2023Review
- Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs.Frontiers in cellular neuroscience · 2023Article
- Cochlear implant material effects on inflammatory cell function and foreign body response.Hearing research · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Cell composition at the vitreomacular interface in traumatic macular holes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
hypothesisCochlear implantation may cause an increase in the number of macrophages in the human cochlea similar to previous findings in the vestibular endorgans.
backgroundMacrophages play a key role in both an inflammatory response and homeostatic maintenance. Recently, an increase in the prevalence of macrophages was demonstrated in the human vestibular endorgans after implantation. However, the prevalence of macrophages in the cochlea after implantation is unclear. The aim of this study was to compare the distribution and prevalence of macrophages in implanted human cochleae and the contralateral unimplanted ears.
methodsThe prevalence of macrophages in the cochlea in 10 human subjects who had undergone unilateral cochlear implantation was studied by light microscopy using anti-Iba1 immunostaining. The densities of macrophages in the osseous spiral lamina (OSL) and Rosenthal's canal (RC) in implanted cochleae were compared with the contralateral unimplanted ears. The distribution of macrophage morphology (amoeboid, transitional, and ramified) was also compared.
resultsThere were activated and phagocytosing macrophages within the fibrotic sheath surrounding the electrode track and within fibrous tissue with lymphocytic infiltration in implanted ears. The densities of macrophages in OSL and RC in implanted ears were significantly greater than in unimplanted ears in some areas. There was also a difference in the prevalence of macrophage phenotype between the OSL and RC.
conclusionAn increase in the density of macrophages in the cochlea after cochlear implantation was demonstrated. Both phagocytosis and anti-inflammatory activity of macrophages were suggested by the distribution and prevalence of macrophages in the implanted cochlea.
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