Evidence map›Paper›PMID 31820810›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2020

A prospective study of Escherichia coli bloodstream infection among adolescents and adults in northern Tanzania.

Deng B Madut, Matthew P Rubach, Nathaniel Kalengo, Manuela Carugati, Michael J Maze, Anne B Morrissey, Blandina T Mmbaga, Bingileki F Lwezaula, Kajiru G Kilonzo, Venance P Maro and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Deng B MadutDivision of Infectious Diseases and International Health, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.
Matthew P RubachDivision of Infectious Diseases and International Health, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.
Nathaniel KalengoKilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.
Manuela CarugatiDivision of Infectious Diseases and International Health, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.
Michael J MazeDepartment of Medicine, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Anne B MorrisseyDivision of Infectious Diseases and International Health, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.
Blandina T MmbagaKilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.
Bingileki F LwezaulaMawenzi Regional Referral Hospital, PO Box 3054, Moshi, Tanzania.
Kajiru G KilonzoKilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.
Venance P MaroKilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.
John A CrumpDivision of Infectious Diseases and International Health, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.
Tumaini University · TZDuke Medical Center · USDuke University · USDuke University Hospital · USKilimanjaro Christian Medical Centre · TZSt. Francis Referral Hospital · TZUniversity of Otago · NZ

Funding

International Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0M
Investigating Febrile Deaths in Tanzania (INDITe)R01AI121378 · NIAID · DUKE UNIVERSITY · PI RUBACH, MATTHEW P · 2016 to 2020
$2.7M
The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: UnderR01TW009237 · FIC · DUKE UNIVERSITY · PI CRUMP, JOHN ANDREW · 2011 to 2014
$1.7M
Viral Zoonoses and Severe Febrile Illness in Northern TanzaniaK23AI116869 · NIAID · DUKE UNIVERSITY · PI RUBACH, MATTHEW P · 2016 to 2020
$896k
Biotechnology and Biological Sciences Research Council BB/L018926/1FIC NIH HHS R01 TW009237NIAID NIH HHS K23 AI116869NIAID NIH HHS R01 AI121378NIAID NIH HHS U01 AI062563
6 · The paper itself

Abstract

backgroundCharacterization of the epidemiology of Escherichia coli bloodstream infection (BSI) in sub-Saharan Africa is lacking. We studied patients with E. coli BSI in northern Tanzania to describe host risk factors for infection and to describe the antimicrobial susceptibility of isolates.

methodsWithin 24 h of admission, patients presenting with a fever at two hospitals in Moshi, Tanzania, were screened and enrolled. Cases were patients with at least one blood culture yielding E. coli and controls were those without E. coli isolated from any blood culture. Logistic regression was used to identify host risk factors for E. coli BSI.

resultsWe analyzed data from 33 cases and 1615 controls enrolled from 2007 through 2018. The median (IQR) age of cases was 47 (34-57) y and 24 (72.7%) were female. E. coli BSI was associated with (adjusted OR [aOR], 95% CI) increasing years of age (1.03, 1.01 to 1.05), female gender (2.20, 1.01 to 4.80), abdominal tenderness (2.24, 1.06 to 4.72) and urinary tract infection as a discharge diagnosis (3.71, 1.61 to 8.52). Of 31 isolates with antimicrobial susceptibility results, the prevalence of resistance was ampicillin 29 (93.6%), ceftriaxone three (9.7%), ciprofloxacin five (16.1%), gentamicin seven (22.6%) and trimethoprim-sulfamethoxazole 31 (100.0%).

conclusionsIn Tanzania, host risk factors for E. coli BSI were similar to those reported in high-resource settings and resistance to key antimicrobials was common.

Indexed as

BacteremiaEscherichia coli InfectionsAdolescentAdultAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliFemaleHumansMicrobial Sensitivity TestsProspective StudiesTanzaniaAnti-Bacterial AgentsAfricabacteremiaEscherichia colirisk factorsTanzania

Identifiers

PMID31820810
PMCPMC7197297
OpenAlexW2996364339

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.