ArticleeLife2019
Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
62 citing papers in PubMed, 109 citations in OpenAlex.
- Speech motor cortex enables BCI cursor control and click.Journal of neural engineering · 2025Trial
- Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.Journal of neural engineering · 2020Trial
- In conversation with Sergey Stavisky.Nature neuroscience · 2026Article
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- Article
- Shared latent representations of speech production for cross-patient speech decoding.Nature communications · 2026Article
- Learning-related population dynamics in right and left dorsal premotor cortex during typing skill acquisition.bioRxiv : the preprint server for biology · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome.Cell reports · 2026Article
- Clinical evaluation of communication brain computer interfaces in amyotrophic lateral sclerosis: a landscape analysis.Frontiers in human neuroscience · 2026Article
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- An instantaneous voice-synthesis neuroprosthesis.Nature · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Error encoding in human speech motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Invasive Brain-Computer Interface for Communication: A Scoping Review.Brain sciences · 2025Review
- Whole-brain dynamics of articulatory, acoustic and semantic speech representations.Communications biology · 2025Article
- Decoding semantics from natural speech using human intracranial EEG.bioRxiv : the preprint server for biology · 2025Article
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Speech motor cortex enables BCI cursor control and click.bioRxiv : the preprint server for biology · 2024Article
- Reducing power requirements for high-accuracy decoding in iBCIs.Journal of neural engineering · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
Speaking is a sensorimotor behavior whose neural basis is difficult to study with single neuron resolution due to the scarcity of human intracortical measurements. We used electrode arrays to record from the motor cortex 'hand knob' in two people with tetraplegia, an area not previously implicated in speech. Neurons modulated during speaking and during non-speaking movements of the tongue, lips, and jaw. This challenges whether the conventional model of a 'motor homunculus' division by major body regions extends to the single-neuron scale. Spoken words and syllables could be decoded from single trials, demonstrating the potential of intracortical recordings for brain-computer interfaces to restore speech. Two neural population dynamics features previously reported for arm movements were also present during speaking: a component that was mostly invariant across initiating different words, followed by rotatory dynamics during speaking. This suggests that common neural dynamical motifs may underlie movement of arm and speech articulators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.