ArticleStress (Amsterdam, Netherlands)2020
Learning and memory dysfunction of non-surgery cage-mates of mice with surgery.
Article in Stress (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Have we forgotten something when caring for patients for surgery?Frontiers in medicine · 2022Article
- Genotype- and Age-Dependent Differences in Ultrasound Vocalizations of SPRED2 Mutant Mice Revealed by Machine Deep Learning.Brain sciences · 2021Article
- Paraventricular thalamic nucleus plays a critical role in consolation and anxious behaviors of familiar observers exposed to surgery mice.Theranostics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
A patient can develop cognitive dysfunction and neuroinflammation after surgery. However, it is not known whether these pathological processes occur in people who live together with surgery patients. As an initial step to address this issue in animals, 2 mice with right common carotid arterial exposure were cage-mates with 3 non-surgery mice. Their learning and memory were tested starting 5 days after surgery. Their brain tissues were harvested 1 day or 5 days after surgery. The results showed that mice with surgery and cage-mates of these surgery mice had increased pro-inflammatory cytokines in the brain and dysfunction of learning and memory. Inhibition of inflammation attenuated the cognitive impairment of the cage-mates. These results suggest that dysfunction of complex behavior including learning and memory can occur in non-surgery cage-mates of surgery mice. Additional studies are needed to determine whether this phenomenon exists in larger animals and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.