ArticleOrganic letters2019
Catalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds.
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Intermolecular Reductive Coupling of Ketones and Alkenes under Ferrioxalate Photocatalysis.Journal of the American Chemical Society · 2026Article
- Redox-neutral ketone-olefin coupling enabled by mild ketone-to-ketyl-type radical conversion.Nature chemistry · 2026Article
- Aldehyde-Olefin Couplings by Photoinduced Reduction of Electron-Deficient Olefins with Hantzsch Ester Anions.Angewandte Chemie (International ed. in English) · 2026Article
- Multi-Pathway Study for Oxaliplatin Resistance Reduction.Current issues in molecular biology · 2025Review
- Aldehyde-Olefin Couplings Via Sulfoxylate-Mediated Oxidative Generation of Ketyl Radical Anions.Journal of the American Chemical Society · 2024Article
- Photodriven Sm(III)-to-Sm(II) Reduction for Catalytic Applications.Journal of the American Chemical Society · 2024Article
- Ketyl Radical Coupling Enabled by Polycyclic Aromatic Hydrocarbon Electrophotocatalysts.Journal of the American Chemical Society · 2023Article
- Reductive photoredox transformations of carbonyl derivatives enabled by strongly reducing photosensitizers.Chemical science · 2023Article
- Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents.The Journal of organic chemistry · 2022Article
- Catalytic defluorinative ketyl-olefin coupling by halogen-atom transfer.Chemical science · 2022Article
- Ketone-Olefin Coupling of Aliphatic and Aromatic Carbonyls Catalyzed by Excited-State Acridine Radicals.Journal of the American Chemical Society · 2022Article
- Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross-Coupling: Development, Scope, and Applications.Journal of the American Chemical Society · 2022Article
- Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry.Chemical reviews · 2022Review
- Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis.Chemical reviews · 2022Review
- Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis.Journal of the American Chemical Society · 2021Article
- Electroreductive Olefin-Ketone Coupling.Journal of the American Chemical Society · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Generation of a ketyl radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described. The method is applicable to both aliphatic ketones and aldehydes to afford the corresponding tertiary and secondary alcohols in continuous flow and batch. Preliminary mechanistic investigation suggests the catalytic formation of a ketyl radical intermediate.
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Registered trials
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