Evidence map›Paper›PMID 31820518›Full record

ArticleNMR in biomedicine2020

Correlations of cortical bone microstructural and mechanical properties with water proton fractions obtained from ultrashort echo time (UTE) MRI tricomponent T2* model.

Saeed Jerban, Xing Lu, Erik W Dorthe, Salem Alenezi, Yajun Ma, Lena Kakos, Hyungseok Jang, Robert L Sah, Eric Y Chang, Darryl D'Lima and 1 more

Abstract read
In one paragraph

Article in NMR in biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  5. Article
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  7. Article
  8. In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024
    Review
  9. Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Longitudinal 3T MRI TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  17. Article
  18. Review
  19. Compositional evaluation of lesion and parent bone in patients with juvenile osteochondritis dissecans of the knee using TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saeed JerbanDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6450-2892
Xing LuDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Erik W DortheShiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, USA.
Salem AleneziResearch and Laboratories Sector, Saudi Food and Drug Authority, Riyadh, KSA.
Yajun MaDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0830-9232
Lena KakosDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Hyungseok JangDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-3597-9525
Robert L SahDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Eric Y ChangDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Darryl D'LimaShiley Center for Orthopedic Research and Education at Scripps Clinic, La Jolla, CA, USA.
Jiang DuDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9203-2450

Funding

Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of BoneR01AR068987 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2024
$4.9M
Quantitative UTE MR Imaging: Sensitive Biomarkers for OsteoarthritisR01AR062581 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2013 to 2022
$4.1M
UTE Magnetic Resonance Imaging: New Biomarkers for Multiple SclerosisR01NS092650 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2019
$1.9M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
Ultrashort Echo Time Magnetic Resonance Imaging of Bone Stress InjuriesR21AR073496 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2018 to 2019
$343k
Quantitative Measurement of Joint pH with Magnetic Resonance ImagingI01RX002604 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, ERIC Y · 2018 to 2022
–
Quantitative Magnetic Resonance Imaging of Human Rotator Cuff TendonI01CX001388 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, ERIC Y · 2016 to 2024
–
CSRD VA I01 CX001388NIAMS NIH HHS R01 AR062581NIAMS NIH HHS R01 AR068987NIAMS NIH HHS R01 AR075825NIAMS NIH HHS R21 AR073496NINDS NIH HHS R01 NS092650RRD VA I01 RX002604
6 · The paper itself

Abstract

Mechanical and microstructural evaluations of cortical bone using ultrashort echo time magnetic resonance imaging (UTE-MRI) have been performed increasingly in recent years. UTE-MRI acquires considerable signal from cortical bone and enables quantitative bone evaluations. Fitting bone apparent transverse magnetization (T2*) decay using a bicomponent model has been regularly performed to estimate bound water (BW) and pore water (PW) in the quantification of bone matrix and porosity, respectively. Human cortical bone possesses a considerable amount of fat, which appears as MRI T2* signal oscillation and can subsequently lead to BW overestimation when using a bicomponent model. Tricomponent T2* fitting model has been developed to improve BW and PW estimations by accounting for fat contribution in the MRI signal. This study aimed to investigate the correlations of microstructural and mechanical properties of human cortical bone with water pool fractions obtained from a tricomponent T2* model. 135 cortical bone strips (~4 × 2 × 40 mm

Indexed as

Magnetic Resonance ImagingProtonsBiomechanical PhenomenaCortical BoneFemaleHumansLinear ModelsMaleMiddle AgedTime FactorsWaterX-Ray MicrotomographyProtonsWaterbone mechanicscortical bonefatMRIT2* fitting modelultrashort echo time

Identifiers

PMID31820518
PMCPMC7161421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.