ReviewJournal of cardiovascular translational research2020
Vascular Pathways of Testosterone: Clinical Implications.
Review in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Application of the latest CLSI EP guidelines in light-initiated chemiluminescent assay for testosterone.Journal of medical biochemistry · 2026Article
- Testosterone and Cardiovascular Health: Physiology, Pharmacokinetics and Clinical Implications.Cardiology and cardiovascular medicine · 2026Article
- Distinct patterns of hypogonadism in a cross-sectional study of Malaysian men with type 2 diabetes mellitus: The role of insulin resistance, visceral adiposity, and aging.Journal of diabetes investigation · 2025Article
- Sex Difference of Alcoholic Hypertension: Mechanism and Targeted Therapy.Current hypertension reports · 2025Review
- Vitamin D Status Determines Cardiometabolic Effects of Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism.Nutrients · 2025Article
- Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health.Medical review (2021) · 2024Review
- Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.The neuroradiology journal · 2024Article
- Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia.Current issues in molecular biology · 2024Review
- Low Muscle Mass is Independently Associated with an Increased Risk of Having Lower Limb Atherosclerosis in T2DM Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Lower serum testosterone is associated with increased likelihood of arthritis.Scientific reports · 2023Article
- Relationship between testosterone and male bladder cancer.Scientific reports · 2023Article
- Article
- The Role of Adiponectin in the Resolution of Male-Obesity-Associated Secondary Hypogonadism after Metabolic Surgery and Its Impact on Cardiovascular Risk.Biomedicines · 2022Article
- Correlation between nongenomic action of C19-steroids and COVID-19 severity.Physiological research · 2021Review
- Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats.Current issues in molecular biology · 2021Article
- miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics.Frontiers in pharmacology · 2021Article
- Editorial: Gender Differences in Cardiovascular Diseases.Journal of cardiovascular translational research · 2020Article
- Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms.In vivo (Athens, Greece)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Several studies have shown a correlation between low T levels and an increased prevalence of several CVD. These observations suggest that T has beneficial effects on the cardiovascular system and that testosterone replacement therapy may become a therapeutic reality for some of these disorders. Graphical abstract .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.