Evidence map›Paper›PMID 31820303›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2020

Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats.

Yinuer Ha, Tingrui Wang, Jianhuang Li, Jun Li, Ruohuang Lu, Jing Li, Lin Chen, Pingping Gan

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Liquorice for pain?Therapeutic advances in psychopharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yinuer HaKey Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China.
Tingrui WangDepartment of Neurology, Binzhou Central Hospital, Binzhou Medical College, Binzhou, 251700, China.
Jianhuang LiDepartment of Oncology,Xiangya Hospital, Central South University, No. 87 of Xiangya Road, Changsha, 410008, Hunan, China.
Jun LiDepartment of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Urumchi Middle Road, Jing'an District, Shanghai, 200040, China.
Ruohuang LuDepartment of Stomatology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Jing LiDepartment of New Drug R&D, JS InnoPharm(Shanghai) Ltd., Shanghai, 201319, China.
Lin ChenKey Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China.
Pingping GanDepartment of Oncology,Xiangya Hospital, Central South University, No. 87 of Xiangya Road, Changsha, 410008, Hunan, China. gppxy@csu.edu.cn.
Xiangya Hospital Central South University · CNBinzhou Medical University · CNCentral South University · CNHuashan Hospital · CNThird Xiangya Hospital · CN

Funding

the National Natural Science Foundation of China 81202781the Natural Science Foundation of Hunan Province, China 2019JJ50960
6 · The paper itself

Abstract

BACKGROUND AND

objectivesLicorice is the dried roots and rhizomes of Glycyrrhiza uralensis Fisch (Leguminosae), which is often used with paclitaxel to alleviate paclitaxel-induced pain in clinics. However, the herb-drug interaction between licorice and paclitaxel is still unknown. Our study evaluates the effects of oral licorice on the paclitaxel in rats via pharmacokinetic studies.

methodsA simple and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to determine paclitaxel in rat. SD rats were randomly divided into 3 groups of 6 animals each as follows: two groups of rats that were pretreated with a daily gavage of licorice (3 g/kg) for 1 or 14 successive days; Control group that was administered distilled water. All rats were then intravenously administered with paclitaxel (3 mg/kg).

resultsThe results showed that 14 days pretreatment of licorice could decrease the area under the curve (AUC

conclusionsThe results will contribute to better use of licorice in the adjunctive therapy and provide information to study the interaction between herbs and chemotherapy.

Indexed as

Herb-Drug InteractionsAnimalsAntineoplastic Agents, PhytogenicArea Under CurveChromatography, High Pressure LiquidGlycyrrhizaMalePaclitaxelPlant ExtractsRatsRats, Sprague-DawleyTandem Mass SpectrometryAntineoplastic Agents, PhytogenicPaclitaxelPlant Extracts

Identifiers

PMID31820303
OpenAlexW2993798201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.