Evidence map›Paper›PMID 31820278›Full record

ArticleMolecular and cellular biochemistry2020

Potential therapeutic effects of antagonizing adenosine A

Tarek K Motawi, Nermin A H Sadik, Manal A Hamed, Sanaa A Ali, Wagdy K B Khalil, Yomna R Ahmed

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 68 citations in OpenAlex.

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  14. The Promise of Niacin in Neurology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tarek K MotawiBiochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Nermin A H SadikBiochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Manal A HamedDepartment of Therapeutic Chemistry, National Research Centre, El-Buhouth St., Dokki, Giza, 12622, Egypt. manal_hamed@yahoo.com.ORCID http://orcid.org/0000-0003-3643-5842
Sanaa A AliDepartment of Therapeutic Chemistry, National Research Centre, El-Buhouth St., Dokki, Giza, 12622, Egypt.
Wagdy K B KhalilCell Biology Department, National Research Centre, El-Buhouth St., Dokki, Giza, 12622, Egypt.
Yomna R AhmedDepartment of Therapeutic Chemistry, National Research Centre, El-Buhouth St., Dokki, Giza, 12622, Egypt.
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and non-dopaminergic drugs in mice model of Parkinson's disease through behavioral, biochemical, genetic and histopathological observations. Mice treated with rotenone rerecorded significant increase in adenosine A

Indexed as

Parkinson Disease, SecondaryAdenosine A2 Receptor AntagonistsAnimalsCurcuminDisease Models, AnimalHippocampusHumansMaleMiceNeuroprotective AgentsNiacinReceptor, Adenosine A2ARotenoneSubstantia NigraAdenosine A2 Receptor AntagonistsAdora2a protein, mouseCurcuminNeuroprotective AgentsNiacinReceptor, Adenosine A2ARotenoneCurcuminNiacinParkinson’s diseaseRotenoneZM241385

Identifiers

PMID31820278
OpenAlexW2994896547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.