Evidence map›Paper›PMID 31820125›Full record

ArticleSports medicine - open2019

Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study.

David Varillas Delgado, Juan José Tellería Orriols, Carlos Martín Saborido

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Article in Sports medicine - open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

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10citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

David Varillas DelgadoElite and High-Performance Athletes Research Group, Research Unit, Faculty of Medicine, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain. david.varillas@ufv.es.ORCID http://orcid.org/0000-0002-0227-2419
Juan José Tellería OrriolsElite and High-Performance Athletes Research Group, Institute of Biology and Molecular Genetics (IBMG/CSIC), University of Valladolid, Valladolid, Spain.
Carlos Martín SaboridoFundación San Juan de Dios. Faculty of Health Sciences San Rafael, Nebrija University, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genetic profile that is needed to define an endurance athlete has been studied during recent years. The main objective of this work is to approach for the first time the study of genetic variants in liver-metabolizing genes and their role in endurance performance by comparing the allelic and genotypic frequencies in elite endurance athletes to the non-athlete population.

methodsGenotypic and allelic frequencies were determined in 123 elite endurance athletes (75 professional road cyclists and 48 endurance elite runners) and 122 male non-athlete subjects (sedentary). Genotyping of cytochrome P450 family 2 subfamily D member 6 (CYP2D6 rs3892097), glutathione-S transferase mu isoform 1 (GSTM1), glutathione S-transferase pi (GSTP rs1695) and glutathione S-transferase theta (GSTT) genes was performed by polymerase chain reaction (PCR). The combination of the polymorphisms for the "optimal" polygenic profile has been quantified using the genotype score (GS).

resultsStatistical differences were found in the genetic distributions between elite endurance athletes and non-athletes in CYP2D6 (p < 0.001) and GSTT (p = 0.014) genes. The binary logistic regression model showed a favourable OR (odds ratio) of being an elite endurance runner against a professional road cyclist (OR: 2.403, 95% CI: 1.213-4.760 (p = 0.002)) in the polymorphisms studied.

conclusionsGenotypic distribution of liver-metabolizing genes in elite endurance athletes is different to non-athlete subjects, with a favourable gene profile in elite endurance athletes in terms of detoxification capacity.

Indexed as

CYP2D6Cytochrome p 450Glutathione transferasesPerformancePhysical enduranceSports

Identifiers

PMID31820125
PMCPMC6901632

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