ReviewDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2020
[Uveal melanoma : Early detection as the key to successful personalized medicine].
Review in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- [Personalized medicine in the treatment of eye tumors : Connection between molecular biology, clinical aspects and personal needs of patients].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersonalized medicine in the oncological care of patients aims to ensure the best possible outcome for patients by tailoring the diagnostics and treatment to the individual. This goal also applies to patients with uveal melanoma (UM).
objectiveThe aim of this article is to define the present and future potential of personalized medicine and maximize its benefits in patients with UM.
methodsThis article gives an overview of current theranostics for UM and describes a recent paradigm shift in diagnostics and the potential impact of new therapeutic developments.
resultsTreatment is initiated when the diagnosis of UM is histologically confirmed or is very probable based on clinical characteristics. Current treatment concepts are primarily influenced by various factors, such as the anatomical features of the primary tumor, situation of the contralateral eye and also the age, health status and wishes of the patient. The current treatment and control of the primary tumor are very successful but they have little influence on the development of metastases and life expectation. The life expectation of the patient essentially depends on the timing of the diagnosis and treatment of the UM. The liquid biopsy is a new diagnostic tool that supports an early decision for a more invasive diagnostic procedure or treatment. Molecular biological techniques enable a risk stratification and provide a foundation for decision making for neoadjuvant forms of treatment.
conclusionThe present concept of personalized medicine for UM is restricted to the treatment of the primary tumor. New diagnostic options, such as liquid biopsy and molecular genetic investigations help to acquire a better understanding of the mechanisms involved and provide the foundation for precision medicine in the development of further personalized treatment concepts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.