Evidence map›Paper›PMID 31819768›Full record

ArticleExperimental and therapeutic medicine2019

Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37.

Teodor Ștefanache, Norina Forna, Magda Bădescu, Daniela Jitaru, Mihaiela Loredana Dragos, Ciprian Rezuș, Bogdan Mihail Diaconescu, Oana Bădulescu, Elena Rezuș, Manuela Ciocoiu and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Teodor ȘtefanacheDepartment of Pathophysiology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Norina FornaDepartment of Implantology, Dental Medicine, 700115 Iaşi, Romania.
Magda BădescuDepartment of Pathophysiology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Daniela JitaruRegional Institute of Oncology Iasi, 700115 Iaşi, Romania.
Mihaiela Loredana DragosRegional Institute of Oncology Iasi, 700115 Iaşi, Romania.
Ciprian RezușDepartment of Internal Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Bogdan Mihail DiaconescuDepartment of Pathophysiology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Oana BădulescuDepartment of Pathophysiology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Elena RezușRehabilitation Hospital of Iasi, Rheumatology Clinic, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Manuela CiocoiuDepartment of Pathophysiology, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Codruta BădescuDepartment of Internal Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iaşi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · ROInstitutul Regional de Oncologie · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is common knowledge that some natural antimicrobial peptides also have a tumoricidal effect. We have shown that the peptides defensin and cathelicidin LL37 have cytostatic effects on human tumor cell lines HT29 (colorectal carcinoma) and A549 (alveolar carcinoma). In order to determine the modulating mechanism of these peptides we assessed the gene expression of the

Indexed as

cathelicidindefensingene expression

Identifiers

PMID31819768
PMCPMC6895780
OpenAlexW2981867759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.