Evidence map›Paper›PMID 31819750›Full record

ArticleARYA atherosclerosis2019

The effect of canola oil compared with sesame and sesame-canola oil on cardio-metabolic biomarkers in patients with type 2 diabetes: Design and research protocol of a randomized, triple-blind, three-way, crossover clinical trial.

Mojgan Amiri, Mohammad Taghi Ghaneian, Mohammad Javad Zare-Sakhvidi, Masoud Rahmanian, Azadeh Nadjarzadeh, Fatemeh Moghtaderi, Hamidreza Raeisi-Dehkordi, Alireza Zimorovat, Fateme Jafari, Javad Zavar-Reza and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ARYA atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Natural Products in the Clinical Management of Metabolic Syndrome.Handbook of experimental pharmacology · 2025
    Review
  5. Review
  6. The combined effects of cholesteryl ester transfer protein (Journal of cardiovascular and thoracic research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mojgan AmiriNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Taghi GhaneianProfessor, Environmental Science and Technology Research Center AND Department of Environmental Health Engineering, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Javad Zare-SakhvidiAssociate Professor, Occupational Health Research Center AND Department of Occupational Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud RahmanianAssistant Professor, Diabetes Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Azadeh NadjarzadehAssociate Professor, Nutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemeh MoghtaderiNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hamidreza Raeisi-DehkordiNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Alireza ZimorovatNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fateme JafariNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Javad Zavar-RezaProfessor, Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Alireza Jahan-MihanAssociate Professor, Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
Mohammad Reza Aghaei-MeybodiDiabetes Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Amin Salehi-AbargoueiAssociate Professor, Nutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRDiabetes Research Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth canola and sesame oils consumption have been associated with favorable effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has compared their effects on cardiovascular risk factors. The present study aimed to assess the effect of canola, sesame, and sesame-canola oils consumption on cardio-metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).

methodsThis study was a randomized, triple-blind, three-way, crossover clinical trial. The study participants included 102 individuals with T2DM. Their spouses were also included in the study. The participants were entered into a 4-week run-in period. After that, their regular dietary oil was replaced with canola, sesame, or sesame-canola oils (a blend of sesame and canola oils) in three 9-week phases, which were separated by two 4-week washout periods (sunflower oil was consumed during the run-in and the washout periods). Dietary, physical activity, blood pressure, and anthropometric measurements were assessed at the beginning, in the middle (week 4-5), and at the end of each treatment phase. Blood samples were taken at the beginning and at the end of each phase. Serum, plasma, buffy coat, and whole blood samples were extracted and kept at -80 ºC for further analysis. Serum fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were selected as the primary outcomes.

results102 participants with T2DM were randomly assigned to one of the 6 rolling methods. Through them, 93 individuals (91.2%) completely participated in all phases.

conclusionThe present study will provide an exceptional opportunity to examine the effect of canola, sesame, and sesame-canola oil on cardio-metabolic markers in adults with and without T2DM. This trial will also provide a good medium for the investigation of gene-dietary oils interaction in the future.

Indexed as

Canola OilCardiovascular DiseasesClinical TrialSesame OilType 2 Diabetes Mellitus

Identifiers

PMID31819750
PMCPMC6884729
OpenAlexW2981259213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.