Evidence map›Paper›PMID 31819629›Full record

ArticleCancer management and research2019

AMPH-1 As A Critical Tumor Suppressor That Inhibits Osteosarcoma Progression.

Haiyun Zhang, Yujie Liu, Kehan Xu, Kai Mao, Weidong Han, Feifan Xu, Wei Wan, Yajun Sun

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haiyun Zhang *Department of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China.
Yujie Liu *Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Kehan Xu *Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Kai MaoDepartment of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China.
Weidong HanDepartment of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China.
Feifan XuDepartment of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China.
Wei WanDepartment of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
Yajun SunDepartment of Laboratory Medicine, The Fourth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China.
Second Military Medical University · CNSecond People's Hospital of NanTong · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAmphiphysin 1 (AMPH-1) is involved in endocytosis, and its expression is upregulated in osteosarcoma compared with osteofibrous dysplasia.

methodsWe investigated the role of AMPH-1 in osteosarcoma cells via both gain-of-function and loss-of-function experiments.

resultsKnockdown of

conclusionThese data suggest that AMPH-1 plays an important role in osteosarcoma and may represent a novel therapeutic target for osteosarcoma treatment.

Indexed as

AMPH-1ERK signaling pathwayosteosarcoma

Identifiers

PMID31819629
PMCPMC6883929
OpenAlexW2989725524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.