ArticleNeuropsychiatric disease and treatment2019
Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Frequency-dependent alterations in functional connectivity in patients with Alzheimer's Disease spectrum disorders.Frontiers in aging neuroscience · 2024Article
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlcohol dependence (AD) is a relapsing mental disorder, typically occurring with concurrent tobacco misuse. Studies have reported disruption of the structural connectivity between hemispheres in the brain of individuals with AD. However, alterations in interhemispheric interactions and the specificity of frequency bands in individuals with AD remain unknown. Voxel-mirrored homotopic connectivity (VMHC) allows examination of functional interactions between mirrored interhemispheric voxels. Here, we use VMHC to investigate homotopic connectivity in AD and alcohol and nicotine co-dependence (AND) subjects. PATIENTS AND
methodsVMHC and seed-based functional connectivity (FC) in 24 AD, 30 AND, and 35 sex-, age-, and education-matched healthy control (HC) subjects were calculated for different frequency bands (slow-5, slow-4, and typical bands).
resultsIndividuals with AD demonstrated significantly reduced VMHC in bilateral cerebellum posterior lobe (CPL) and increased VMHC in bilateral middle frontal gyrus (MFG) compared to that in HCs in the typical and slow-4 bands; higher VMHC in the MFG was positively correlated with the dependence-severity score. In all bands of the VMHC analysis, no significant differences were found between the AND and other groups. Subsequent seed-based FC analysis demonstrated all regions with abnormal VMHC exhibited altered FC with its counterpart in the contralateral hemisphere in the typical and slow-4 frequency bands. The FC value between bilateral CPL within AD subjects negatively correlated with alcohol intake.
conclusionOur findings provide further evidence of the role of disruptions within the brain circuitry supporting cognitive control in the development of AD. Alterations in neural activities in the CPL and MFG might be a biomarker of dependence severity in AD patients as assessed using clinical questionnaire and features. Because of the frequency specificity in VMHC, we must consider frequency effects in future AD functional magnetic resonance imaging studies.
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