Evidence map›Paper›PMID 31819427›Full record

ArticleInternational journal of nanomedicine2019

Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials.

Rafal Pokrowiecki, Jacek Wojnarowicz, Tomasz Zareba, Iwona Koltsov, Witold Lojkowski, Stefan Tyski, Agnieszka Mielczarek, Pawel Zawadzki

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Genetic Stability and Photosystem II Functioning of In Vitro-RecoveredInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Recent progress in carbon dots for anti-pathogen applications in oral cavity.Frontiers in cellular and infection microbiology · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Zinc Oxide Nanoparticles: A Review on Its Applications in Dentistry.Frontiers in bioengineering and biotechnology · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rafal PokrowieckiDepartment of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0001-8604-1468
Jacek WojnarowiczInstitute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland.ORCID 0000-0002-6106-5188
Tomasz ZarebaDepartment of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland.ORCID 0000-0003-2000-8248
Iwona KoltsovInstitute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland.ORCID 0000-0001-6523-3719
Witold LojkowskiInstitute of High Pressure Physics, Polish Academy of Sciences, Warsaw, Poland.ORCID 0000-0001-8521-0688
Stefan TyskiDepartment of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland.ORCID 0000-0003-3352-038X
Agnieszka MielczarekDepartment of Conservative Dentistry, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0003-0355-2305
Pawel ZawadzkiDepartment of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0002-2599-1627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aims of this study were to investigate new nano-formulations based on ZnO and Ag nanoparticle (NP) compounds when used against clinical strains of oral gram-positive and gram-negative bacteria, and to examine the stability and behaviour of nano-formulation mixtures in saliva based on different compositions of Ag NPs, ZnO NPs and ZnO+x·Ag NPs.

resultsThe NP mixtures had an average size of 30±3 nm, while the commercial Ag NPs had an average size of 55±5 nm. The suspensions displayed differing antibacterial activities and kinetics of destabilisation processes, depending on NPs composition and fluid types.

conclusionThe present study showed that all NPs suspensions displayed significant destabilisation and high destabilisation over the 24 h of the analyses. The agglomeration processes of NPs in human saliva can be reversible.

Indexed as

Drug Delivery SystemsAdolescentAdultAnti-Bacterial AgentsBacteriaBiocompatible MaterialsFemaleHumansMaleMetal NanoparticlesMicrobial Sensitivity TestsMiddle AgedParticle SizeSalivaSilverSpectroscopy, Fourier Transform InfraredAnti-Bacterial AgentsBiocompatible MaterialsSilverZinc Oxidebacteriacontrolled drug releasemetal nanoparticlesnanomaterialsnanoparticles

Identifiers

PMID31819427
PMCPMC6886554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.