Evidence map›Paper›PMID 31819387›Full record

Trial reportClinical interventions in aging2019

Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol.

Blanca Olivia Murillo Ortiz, Alma Rosa Fuentes Preciado, Joel Ramírez Emiliano, Sandra Martínez Garza, Edna Ramos Rodríguez, Luz Angélica de Alba Macías

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical interventions in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  4. Antioxidants for adults with chronic kidney disease.The Cochrane database of systematic reviews · 2023
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  20. Caloric restriction induced epigenetic effects on aging.Frontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Blanca Olivia Murillo OrtizClinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, León, Guanajuato, Mexico.ORCID 0000-0003-4775-2755
Alma Rosa Fuentes PreciadoDepartment of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico.
Joel Ramírez EmilianoDepartment of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico.ORCID 0000-0001-9813-9120
Sandra Martínez GarzaClinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, León, Guanajuato, Mexico.ORCID 0000-0002-2153-6619
Edna Ramos RodríguezRegional General Hospital No. 58, Mexican Institute Social Security, León, Guanajuato, Mexico.
Luz Angélica de Alba MacíasDepartment of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico.
Mexican Social Security Institute · MXUniversidad de Guanajuato · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.

methodsWe included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).

resultsSignificant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 ± 518.73 vs 1795.65 ± 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 ± 69.21 vs 50.19 ± 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 ± 0.75 vs 2.50 ± 0.85; p = 0.50). DISCUSSION: The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.

Indexed as

Dietary SupplementsRenal DialysisAdultAnti-Inflammatory Agents, Non-SteroidalAntioxidantsBone DensityCurcuminDouble-Blind MethodFemaleFerritinsHumansIron OverloadMaleMiddle AgedMusclesRenal Insufficiency, ChronicAnti-Inflammatory Agents, Non-SteroidalAntioxidantsCurcuminFerritinsResveratrolTriglycerideschronic kidney diseasecurcuminrecovery of bone and muscle massresveratrol

Identifiers

PMID31819387
PMCPMC6873966
OpenAlexW2987302174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.