Evidence map›Paper›PMID 31819341›Full record

ArticleMolecular vision2019

Melatonin receptor heterodimerization in a photoreceptor-like cell line endogenously expressing melatonin receptors.

Aída Sánchez-Bretaño, Ting-Chung Suen, Kenkichi Baba, Jason DeBruyne, Gianluca Tosini

Abstract read
In one paragraph

Article in Molecular vision, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Modeling the Heterodimer Interfaces of Melatonin Receptors.Frontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aída Sánchez-BretañoDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Ting-Chung SuenDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Kenkichi BabaDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Jason DeBruyneDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Gianluca TosiniDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.

Funding

Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
TRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI LIU, DONG · 1986 to 2011
$32.4M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
WARCEFU54RR026137 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI HARRIS-HOOKER, SANDRA · 2009 to 2011
$14.6M
Program Evaluation - Internal & External U54NS083932 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MACLEISH, PETER RAYMOND · 2013 to 2017
$7.7M
Circadian regulation of RPE functionsR01EY026291 · NEI · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2016 to 2020
$2.1M
Photic and Circadian Regulation of Retinal MelatoninR01EY022216 · NEI · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2012 to 2015
$1.4M
Retinal Circadian Rhythms and Photoreceptors ViabilitySC2GM116760 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI BABA, KENKICHI · 2016 to 2018
$426k
NCRR NIH HHS G12 RR003034NCRR NIH HHS U54 RR026137NEI NIH HHS R01 EY022216NEI NIH HHS R01 EY026291NIGMS NIH HHS SC2 GM116760NIMHD NIH HHS S21 MD000101NIMHD NIH HHS U54 MD007588NINDS NIH HHS U54 NS083932
6 · The paper itself

Abstract

Purpose: Melatonin signaling plays an important role in the modulation of retinal physiology and photoreceptor viability during aging. In this study, we investigated whether 661W cells-a photoreceptor-like cell that endogenously expresses melatonin receptor type 1 (MT Methods: 661W cells were cultured, and MT Results: The results demonstrated that heterodimerization of MT Conclusions: The data indicated that in 661W cells, MT

Indexed as

Protein MultimerizationAnimalsCell LineCyclic AMPExtracellular Signal-Regulated MAP KinasesMelatoninMicePhotoreceptor Cells, VertebrateProto-Oncogene Proteins c-aktReceptor, Melatonin, MT1Receptor, Melatonin, MT2Signal TransductionCyclic AMPExtracellular Signal-Regulated MAP KinasesMelatoninProto-Oncogene Proteins c-aktReceptor, Melatonin, MT1Receptor, Melatonin, MT2

Identifiers

PMID31819341
PMCPMC6887793

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.