ArticleNature microbiology2020
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 163 papers.
0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 292 citations in OpenAlex.
- Exogenous indole promotes florfenicol tolerance inVirulence · 2026Article
- Rare Earth-Silver Synergistic Strategy: Preparation of a Potential Antibacterial Material for Wound Related Applications.ACS omega · 2026Article
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- Reply to Gong et al.: Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zinc oxide/copper ferrite ferrofluids derived from natural resources for antifungal applications.Discover nano · 2026Article
- Mechanism of persister formation in response to nitrogen starvation.Nature communications · 2026Article
- Article
- Implications of bacterial exposure to reactive oxygen and chlorine species.Infection and immunity · 2026Review
- Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.Trends in genetics : TIG · 2026Review
- The Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Crosstalk Between Oxidative Stress and M1/M2 Microglial Polarization Following Ischemic Stroke.Molecular neurobiology · 2026Review
- Host-driven remodelling of theMicrobiology (Reading, England) · 2026Review
- Emerging host-directed strategies for overcoming drug resistance and immune evasion in Staphylococcus aureus infections.Journal of advanced research · 2026Review
- Peptidoglycan Recognition Protein-S as a Dual-Action Antimicrobial and Immunomodulatory Agent Against Staphylococcus aureus.Probiotics and antimicrobial proteins · 2026Article
- Expression patterns of core metabolic genes and elevated intracellular ROS confer drug tolerance inMicrobiology spectrum · 2026Article
- Clemizole inhibits CrtN-driven staphyloxanthin biosynthesis in Staphylococcus aureus to enhance host immune clearance.Communications biology · 2026Article
- Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.Nature reviews. Microbiology · 2026Review
- The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Epigenetic Mechanisms of Antibiotic Resistance.Current molecular medicine · 2026Review
- Molecular Basis of Persister Awakening and Lag-Phase Recovery inInternational journal of molecular sciences · 2026Review
103 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Sarah E Rowe *Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nikki J Wagner *Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lupeng LiDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jenna E BeamDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alec D WilkinsonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lauren C RadlinskiDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Qing ZhangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Edward A MiaoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7295-3490
Brian P ConlonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. brian_conlon@med.unc.edu.ORCID http://orcid.org/0000-0002-2155-8375
University of North Carolina at Chapel Hill · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5MInnate immune defenses against a cytosolic capsuleR01AI136920 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Edward A Miao · 2019 to 2026
$3.7MIntestinal epithelial cell exfoliation by caspasesR01AI139304 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2MNatural killer cell cytotoxicity against intracellular bacteriaR01AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2MExploration of ZHX2 as a novel substrate of pVHL and an oncogenic driver of renal cancerR01CA211732 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, QING · 2017 to 2021
$2.1MAntibiotic activities against S. aureus during P. aeruginosa co-infectionR01AI137273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, BRIAN PATRICK · 2018 to 2022
$2.0MRole of caspase-11 in innate immunityR01AI119073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2015 to 2019
$1.7MNatural killer cell cytotoxicity against intracellular bacteriaR56AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2017 to 2017
$291kInvestigating S. aureus persister formation under physiological conditionsK22AI125501 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, BRIAN PATRICK · 2017 to 2018
$269kNCI NIH HHS P30 CA016086NCI NIH HHS R01 CA211732NIAID NIH HHS K22 AI125501NIAID NIH HHS R01 AI119073NIAID NIH HHS R01 AI133236NIAID NIH HHS R01 AI136920NIAID NIH HHS R01 AI137273NIAID NIH HHS R01 AI139304NIAID NIH HHS R56 AI133236NIDDK NIH HHS P30 DK034987
Abstract
Staphylococcus aureus is a major human pathogen that causes an array of infections ranging from minor skin infections to more serious infections, including osteomyelitis, endocarditis, necrotizing pneumonia and sepsis
Indexed as
AnimalsCell LineCitric Acid CycleDisease Models, AnimalDrug Resistance, BacterialFemaleHost Microbial InteractionsHumansImmunity, InnateMacrophagesMiceMice, Inbred C57BLMice, KnockoutNADPH OxidasesNeutrophilsPhagocytosisNADPH Oxidasesneutrophil cytosolic factor 1Reactive Oxygen Species
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.