Evidence map›Paper›PMID 31819198›Full record

ArticleBritish journal of cancer2020

Development of cancer metabolism as a therapeutic target: new pathways, patient studies, stratification and combination therapy.

Adrian L Harris

Abstract readEditorial
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  16. Review
  17. Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability.International journal of molecular sciences · 2020
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Adrian L HarrisMolecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. adrian.harris@oncology.ox.ac.uk.

Funding

Cancer Research UK 18974
6 · The paper itself

Abstract

Cancer metabolism has undergone a resurgence in the last decade, 70 years after Warburg described aerobic glycolysis as a feature of cancer cells. A wide range of techniques have elucidated the complexity and heterogeneity in preclinical models and clinical studies. What emerges are the large differences between tissues, tumour types and intratumour heterogeneity. However, synergies with inhibition of metabolic pathways have been found for many drugs and therapeutic approaches, and a critical role of window studies and translational trial design is key to success.

Indexed as

AnimalsAzetidinesBiomarkers, TumorClinical Trials as TopicDrug Therapy, CombinationFatty AcidsFatty Acid Synthase, Type IGlycolysisHumansMiceMolecular Targeted TherapyNeoplasmsNitrilesPyrazolesSignal Transduction4-(1-(5-(3,4-dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrileAzetidinesBiomarkers, TumorFASN protein, humanFatty AcidsFatty Acid Synthase, Type INitrilesPyrazoles

Identifiers

PMID31819198
PMCPMC6964699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.