Evidence map›Paper›PMID 31819182›Full record

ReviewBritish journal of cancer2020

Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells.

Cong Hu, Bo Pang, Guangzhu Lin, Yu Zhen, Huanfa Yi

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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  5. Myeloid-derived suppressor cells in sepsis: drivers of persistent immunosuppression and targets for precision immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cong Hu *Central Laboratory, The First Hospital of Jilin University, 130031, Changchun, Jilin, China.
Bo Pang *Central Laboratory, The First Hospital of Jilin University, 130031, Changchun, Jilin, China.
Guangzhu Lin *Department of Cardiology, The First Hospital of Jilin University, 130031, Changchun, Jilin, China.
Yu ZhenDepartment of Dermatology, The First Hospital of Jilin University, 130021, Changchun, Jilin, China.
Huanfa YiCentral Laboratory, The First Hospital of Jilin University, 130031, Changchun, Jilin, China. yihuanfa@jlu.edu.cn.
Jilin University · CNMinistry of Education of the People's Republic of China · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a large number of studies have been carried out in the field of immune metabolism, highlighting the role of metabolic energy reprogramming in altering the function of immune cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathological conditions, such as cancer, inflammation, and infection, and show remarkable ability to suppress T-cell responses. These cells can also change their metabolic pathways in response to various pathogen-derived or inflammatory signals. In this review, we focus on the roles of glucose, fatty acid (FA), and amino acid (AA) metabolism in the differentiation and function of MDSCs in the tumour microenvironment, highlighting their potential as targets to inhibit tumour growth and enhance tumour immune surveillance by the host. We further highlight the remaining gaps in knowledge concerning the mechanisms determining the plasticity of MDSCs in different environments and their specific responses in the tumour environment. Therefore, this review should motivate further research in the field of metabolomics to identify the metabolic pathways driving the enhancement of MDSCs in order to effectively target their ability to promote tumour development and progression.

Indexed as

Amino AcidsCellular ReprogrammingFatty AcidsGlucoseGlycolysisHumansImmunologic SurveillanceMyeloid-Derived Suppressor CellsNeoplasmsT-LymphocytesTumor MicroenvironmentAmino AcidsFatty AcidsGlucose

Identifiers

PMID31819182
PMCPMC6964679
OpenAlexW2992929807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.