ArticleScientific reports2019
Genome investigations show host adaptation and transmission of LA-MRSA CC398 from pigs into Danish healthcare institutions.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Beyond livestock: the genomic evolution and expansion of MRSA CC398 as a healthcare- and community-associated pathogen (2017-2024).Microbial genomics · 2026Article
- From Farm to Fork: Antimicrobial-Resistant Bacterial Pathogens in Livestock Production and the Food Chain.Veterinary sciences · 2025Review
- Simple and accurate genomic classification model for distinguishing between human and pig Staphylococcus aureus.Communications biology · 2024Article
- Time-calibrated phylogenetic and chromosomal mobilome analyses of Staphylococcus aureus CC398 reveal geographical and host-related evolution.Nature communications · 2024Article
- The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2021-2022.EFSA journal. European Food Safety Authority · 2024Article
- A comparison of passive and active dust sampling methods for measuring airborne methicillin-resistant Staphylococcus aureus in pig farms.Annals of work exposures and health · 2023Article
- Biosecurity and Hygiene Procedures in Pig Farms: Effects of a Tailor-Made Approach as Monitored by Environmental Samples.Animals : an open access journal from MDPI · 2023Article
- Fluoroquinolone resistance does not facilitate phage Φ13 integration or excision inAccess microbiology · 2023Article
- A review of new emerging livestock-associated methicillin-resistantVeterinary world · 2023Review
- High Prevalence of Livestock-Associated Methicillin-ResistantTransboundary and emerging diseases · 2023Article
- Prophage-encoded immune evasion factors are critical forCell genomics · 2022Article
- MRSA in Humans, Pets and Livestock in Portugal: Where We Came from and Where We Are Going.Pathogens (Basel, Switzerland) · 2022Review
- A review of horses as a source of spreading livestock-associated methicillin-resistantVeterinary world · 2022Review
- Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion.Nature communications · 2022Article
- Article
- Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2022Article
- Shared antibiotic resistance and virulence genes in Staphylococcus aureus from diverse animal hosts.Scientific reports · 2022Article
- A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Livestock-associated methicillin-resistantFrontiers in microbiology · 2022Article
- How to survive pig farming: Mechanism of SCCFrontiers in microbiology · 2022Article
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8 authors.
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Abstract
Over the last decade, an increasing number of infections with livestock-associated methicillin-resistant Staphylococcus aureus of clonal complex 398 (LA-MRSA CC398) in persons without contact to livestock has been registered in Denmark. These infections have been suggested to be the result of repeated spillover of random isolates from livestock into the community. However, other studies also found emerging sub-lineages spreading among humans. Based on genome-wide SNPs and genome-wide association studies (GWAS), we assessed the population structure and genomic content of Danish LA-MRSA CC398 isolates from healthcare-associated infections from 2014 to 2016 (n = 73) and compared these to isolates from pigs in Denmark from 2014 (n = 183). Phylogenetic analyses showed that most human isolates were closely related to and scattered among pig isolates showing that the majority of healthcare-associated infections are the result of repeated spillover from pig farms, even though cases of human-to-human transmission also were identified. GWAS revealed frequent loss of antimicrobial resistance genes and acquisition of human-specific virulence genes in the human isolates showing adaptation in response to changes in selective pressures in different host environments, which over time could lead to the emergence of LA-MRSA CC398 lineages more adapted to human colonization and transmission.
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