ArticleScientific reports2019
Modeling somatic computation with non-neural bioelectric networks.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Stability and Robustness of a Generalized Pump-Leak Model for Epithelial Vesicles.Bulletin of mathematical biology · 2026Article
- Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Plasmonic imaging of living pancreatic beta-cell networks.Scientific reports · 2026Article
- Consciousness and Energy Processing in Neural Systems.Brain sciences · 2024Article
- Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport.The Journal of general physiology · 2024Article
- A Variational Synthesis of Evolutionary and Developmental Dynamics.Entropy (Basel, Switzerland) · 2023Article
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology.Cellular and molecular life sciences : CMLS · 2023Review
- There's Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines.Biomimetics (Basel, Switzerland) · 2023Article
- Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model.Entropy (Basel, Switzerland) · 2023Article
- Article
- Systems of axon-like circuits for self-assembled and self-controlled growth of bioelectric networks.Scientific reports · 2022Article
- Logical computation with self-assembling electric circuits.PloS one · 2022Article
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Stability and robustness properties of bioelectric networks: A computational approach.Biophysics reviews · 2021Review
- Synthetic living machines: A new window on life.iScience · 2021Review
- Cancer Niches and Their Kikuchi Free Energy.Entropy (Basel, Switzerland) · 2021Article
- Gene regulatory networks exhibit several kinds of memory: quantification of memory in biological and random transcriptional networks.iScience · 2021Article
- A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration.Bioelectricity · 2021Article
- Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?Biology & philosophy · 2021Article
- Cognition Without Neural Representation: Dynamics of a Complex System.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of basal cognition seeks to understand how adaptive, context-specific behavior occurs in non-neural biological systems. Embryogenesis and regeneration require plasticity in many tissue types to achieve structural and functional goals in diverse circumstances. Thus, advances in both evolutionary cell biology and regenerative medicine require an understanding of how non-neural tissues could process information. Neurons evolved from ancient cell types that used bioelectric signaling to perform computation. However, it has not been shown whether or how non-neural bioelectric cell networks can support computation. We generalize connectionist methods to non-neural tissue architectures, showing that a minimal non-neural Bio-Electric Network (BEN) model that utilizes the general principles of bioelectricity (electrodiffusion and gating) can compute. We characterize BEN behaviors ranging from elementary logic gates to pattern detectors, using both fixed and transient inputs to recapitulate various biological scenarios. We characterize the mechanisms of such networks using dynamical-systems and information-theory tools, demonstrating that logic can manifest in bidirectional, continuous, and relatively slow bioelectrical systems, complementing conventional neural-centric architectures. Our results reveal a variety of non-neural decision-making processes as manifestations of general cellular biophysical mechanisms and suggest novel bioengineering approaches to construct functional tissues for regenerative medicine and synthetic biology as well as new machine learning architectures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.