ArticleScientific reports2019
Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Myosin VI depletion delays neuromuscular junction maturation and exacerbates muscle performance.Scientific reports · 2025Article
- Neuromuscular Junction Development Differs Between Extraocular and Skeletal Muscles and Between Different Extraocular Muscles.Investigative ophthalmology & visual science · 2024Article
- Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction.Molecular neurobiology · 2023Article
- Neurexin and neuroligins jointly regulate synaptic degeneration at theFrontiers in cellular neuroscience · 2023Article
- Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury.International journal of molecular sciences · 2022Review
- Three-dimensionalNeural regeneration research · 2022Review
- hiPSC-Derived Schwann Cells Influence Myogenic Differentiation in Neuromuscular Cocultures.Cells · 2021Article
- Morphological remodeling during recovery of the neuromuscular junction from terminal Schwann cell ablation in adult mice.Scientific reports · 2020Article
- More Than Mortar: Glia as Architects of Nervous System Development and Disease.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Synapses undergo transition from polyinnervation by multiple axons to single innervation a few weeks after birth. Synaptic activity of axons and interaxonal competition are thought to drive this developmental synapse elimination and tested as key parameters in quantitative models for further understanding. Recent studies of muscle synapses (endplates) show that there are also terminal Schwann cells (tSCs), glial cells associated with motor neurons and their functions, and vacant sites (or vacancies) devoid of tSCs and axons proposing tSCs as key effectors of synapse elimination. However, there is no quantitative model that considers roles of tSCs including vacancies. Here we develop a stochastic model of tSC and vacancy mediated synapse elimination. It employs their areas on individual endplates quantified by electron microscopy-based analyses assuming that vacancies form randomly and are taken over by adjacent axons or tSCs. The model reliably reproduced synapse elimination whereas equal or random probability models, similar to classical interaxonal competition models, did not. Furthermore, the model showed that synapse elimination is accelerated by enhanced synaptic activity of one axon and also by increased areas of vacancies and tSCs suggesting that the areas are important structural correlates of the rate of synapse elimination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.