ArticleScientific reports2019
A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Association of the TNFRSF1A genotype with lung function impairment in patients with sarcoidosis.Scientific reports · 2026Article
- Americas Association of Sarcoidosis and other granulomatous disorders 2024 conference highlights.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Tobacco smoking and sarcoidosis revisited-Evidence, mechanisms, and clinical implications: a narrative review.Current medical research and opinion · 2025Review
- Sarcoidosis: molecular mechanisms and therapeutic strategies.Molecular biomedicine · 2025Review
- Comparison between diffuse and partial involvement of thoracic lymph nodes on the outcome of sarcoidosis patients.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets.Nature communications · 2023Article
- Molecular Mechanism in the Development of Pulmonary Fibrosis in Patients with Sarcoidosis.International journal of molecular sciences · 2023Review
- Epidemiology of Sarcoidosis in U.S. Veterans from 2003 to 2019.Annals of the American Thoracic Society · 2023Article
- Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study.Circulation. Genomic and precision medicine · 2023Article
- Association between birth by caesarian section and anxiety, self-harm: a gene-environment interaction study using UK Biobank data.BMC psychiatry · 2023Observational
- From Karl Wurm and Guy Scadding's staging toFrontiers in medicine · 2023Article
- Genetic and geographic influence on phenotypic variation in European sarcoidosis patients.Frontiers in medicine · 2023Article
- Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022Review
- Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders.Cell reports. Medicine · 2022Article
- Negative Association of Smoking History With Clinically Manifest Cardiac Sarcoidosis: A Case-Control Study.CJC open · 2022Article
- The Evolving Landscape of Cutaneous Sarcoidosis: Pathogenic Insight, Clinical Challenges, and New Frontiers in Therapy.American journal of clinical dermatology · 2022Review
- Vitamin D and the Risks of Depression and Anxiety: An Observational Analysis and Genome-Wide Environment Interaction Study.Nutrients · 2021Observational
- The intersection of women's health, lung health, and disease.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Epigenetics and sarcoidosis.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Sarcoidosis Following Hematopoietic Stem Cell Transplantation: Clinical Characteristics and HLA Associations.Frontiers in immunology · 2021Article
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Authors and funding
11 authors.
Funding
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Abstract
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren's syndrome (LS) and patients without Löfgren's syndrome (non-LS). To quantify smoking effects in sarcoidosis, we performed a gene-environment interaction study in a Swedish population-based case-control study consisting of 3,713 individuals. Cases and controls were classified according to their cigarette smoking status and genotypes by Immunochip platform. Gene-smoking interactions were quantified by an additive interaction model using a logistic regression adjusted by sex, age and first two principal components. The estimated attributable proportion (AP) was used to quantify the interaction effect. Assessment of smoking effects with inclusion of genetic information revealed 53 (in LS) and 34 (in non-LS) SNP-smoking additive interactions at false discovery rate (FDR) below 5%. The lead signals interacting with smoking were rs12132140 (AP = 0.56, 95% CI = 0.22-0.90), p = 1.28e-03) in FCRL1 for LS and rs61780312 (AP = 0.62, 95% CI = 0.28-0.90), p = 3e-04) in IL23R for non-LS. We further identified 16 genomic loci (in LS) and 13 (in non-LS) that interact with cigarette smoking. These findings suggest that sarcoidosis risk is modulated by smoking due to genetic susceptibility. Therefore, patients having certain gene variants, are at a higher risk for the disease. Consideration of individual's genetic predisposition is crucial to quantify effects of smoking in sarcoidosis.
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