ArticleScientific reports2019
Accentuated osseointegration in osteogenic nanofibrous coated titanium implants.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Janus bilayer coating of functional quaternized chitosan and borate bioactive glass for antibacterial protection and osseointegration.Biomaterials advances · 2026Article
- Metallic topological structures in bone repair implants: Design, properties, and biological interactions.Journal of orthopaedic translation · 2026Review
- The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026Review
- The Influence of the Topical Combined Application of Dexamethasone, Ascorbic Acid, and β-Sodium Glycerophosphate on Implant Osseointegration: A Split-Mouth Randomized Clinical Trial.International journal of dentistry · 2026Article
- Nanofeatured Titanium Surfaces for Dental Implants: A Systematic Evaluation of Osseointegration.Antibiotics (Basel, Switzerland) · 2025Review
- Buccal Mesenchymal Stromal Cells as a Source of Osseointegration of Titanium Implants.Bulletin of experimental biology and medicine · 2024Article
- Additively Manufactured SiOACS applied materials & interfaces · 2024Article
- Micro X-ray Spectral Analysis and Comprehensive In Vivo Study of Modified Titanium Implants.Bulletin of experimental biology and medicine · 2022Article
- X-ray computed microtomography datasets for osteogenic nanofibrous coated titanium implants.Scientific data · 2022Article
- Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiation.Frontiers in bioengineering and biotechnology · 2022Article
- Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits.Clinical oral investigations · 2022Article
- Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections.Bioactive materials · 2021Article
- Osseointegration of a novel dental implant in canine.Scientific reports · 2021Article
- Innovations in Dental Implants Integration: Optimizing dental implants performance utilizing stem cells and coatings.Biotechnology progressReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anchoring of endosseous implant through osseointegration continues to be an important clinical need. Here, we describe the development of superior endosseous implant demonstrating enhance osseointegration, achieved through surface modification via coating of osteogenic nanofibres. The randomized bio-composite osteogenic nanofibres incorporating polycaprolactone, gelatin, hydroxyapatite, dexamethasone, beta-glycerophosphate and ascorbic acid were electrospun on titanium implants mimicking bone extracellular matrix and subsequently induced osteogenesis by targeting undifferentiated mesenchymal stem cells present in the peri-implant niche to regenerate osseous tissue. In proof-of-concept experiment on rabbit study models (n = 6), micro-computed tomography (Micro-CT), histomorphometric analysis and biomechanical testing in relation to our novel osteogenic nanofibrous coated implants showed improved results when compared to uncoated controls. Further, no pathological changes were detected during gross examination and necropsy on peri-implant osseous tissues regenerated in response to such coated implants. The findings of the present study confirm that osteogenic nanofibrous coating significantly increases the magnitude of osteogenesis in the peri-implant zone and favours the dynamics of osseointegration.
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Registered trials
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