ArticleNature communications2019
High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Improving Malaria Parasite Gene Flow Inference Under Sparse Spatial Sampling.Molecular ecology resources · 2026Article
- Measuring changes ineLife · 2025Article
- Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.Nature communications · 2024Article
- Analytic optimization of Plasmodium falciparum marker gene haplotype recovery from amplicon deep sequencing of complex mixtures.PLOS global public health · 2024Article
- Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.Research square · 2023Article
- Sampling for malaria molecular surveillance.Trends in parasitology · 2023Review
- Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2023Article
- How can the complex epidemiology of malaria in India impact its elimination?Trends in parasitology · 2023Review
- Implementing landscape genetics in molecular epidemiology to determine drivers of vector-borne disease: A malaria case study.Molecular ecology · 2023Article
- Performance of SNP barcodes to determine genetic diversity and population structure ofFrontiers in genetics · 2023Article
- Article
- Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: A malaria case study.Molecular ecology resources · 2022Article
- Hotspots and super-spreaders: Modelling fine-scale malaria parasite transmission using mosquito flight behaviour.PLoS pathogens · 2022Article
- Plasmodium falciparum importation does not sustain malaria transmission in a semi-arid region of Kenya.PLOS global public health · 2022Article
- Household Prevalence of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale in the Democratic Republic of the Congo, 2013-2014.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections.Nature communications · 2021Article
- Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.Malaria journal · 2021Article
- Feasibility of pharmacy-based research opportunity to enhance community testing and surveillance.Journal of the American Pharmacists Association : JAPhAArticle
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Authors and funding
8 authors.
Funding
Abstract
Novel interventions that leverage the heterogeneity of parasite transmission are needed to achieve malaria elimination. To better understand spatial and temporal dynamics of transmission, we applied amplicon next-generation sequencing of two polymorphic gene regions (csp and ama1) to a cohort identified via reactive case detection in a high-transmission setting in western Kenya. From April 2013 to July 2014, we enrolled 442 symptomatic children with malaria, 442 matched controls, and all household members of both groups. Here, we evaluate genetic similarity between infected individuals using three indices: sharing of parasite haplotypes on binary and proportional scales and the L1 norm. Symptomatic children more commonly share haplotypes with their own household members. Furthermore, we observe robust temporal structuring of parasite genetic similarity and identify the unique molecular signature of an outbreak. These findings of both micro- and macro-scale organization of parasite populations might be harnessed to inform next-generation malaria control measures.
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