ReviewTranslational psychiatry2019
The rise and fall of MRI studies in major depressive disorder.
Review in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05466851 (An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity.International journal of environmental research and public health · 2023Pooled it
- A systematic review of magnetic resonance imaging in patients with an implanted vagus nerve stimulation system.Neuroradiology · 2021Pooled it
- A data-driven methodological framework for representative recruitment in psychiatric research: insights from the DOCUMENT study.BMC psychiatry · 2026Article
- Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.Psychological medicine · 2026Article
- Glymphatic Dysfunction and Related Brain Structure Changes in Major Depressive Disorder: Effects of Glymphatic Function in Mediating Neuroinflammation.Psychiatry investigation · 2026Article
- 3DViT-GAT: a unified atlas-based 3D vision transformer and graph learning framework for major depressive disorder detection using structural MRI data.Scientific reports · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder.Psychoradiology · 2026Article
- Exploring the potential of polyphenols in major depression: from molecular function to clinical therapy.Frontiers in nutrition · 2026Review
- Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways.Circulation. Cardiovascular imaging · 2026Article
- Characterization of Brain Abnormalities in Lactational Neurodevelopmental Poly I:C Rat Model of Schizophrenia and Depression Using Machine-Learning and Quantitative MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder.World journal of psychiatry · 2025Article
- Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder.Molecular psychiatry · 2025Article
- Influence of Inter-Parental Conflict on New-Onset Major Depressive Disorder in Chinese College Students.Psychology research and behavior management · 2025Article
- Multi-atlas ensemble graph neural network model for major depressive disorder detection using functional MRI data.Frontiers in computational neuroscience · 2025Article
- An objective quantitative diagnosis of depression using a local-to-global multimodal fusion graph neural network.Patterns (New York, N.Y.) · 2024Article
- Alterations of Sensory-related Functional Brain Network Connectivity inPhenomics (Cham, Switzerland) · 2024Article
- Transcriptional patterns of amygdala functional connectivity in first-episode, drug-naïve major depressive disorder.Translational psychiatry · 2024Article
- Deconstructing depression by machine learning: the POKAL-PSY study.European archives of psychiatry and clinical neuroscience · 2024Article
- ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling.iScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural and functional brain alterations are common in patients with major depressive disorder (MDD). In this review, we assessed the recent literature (1995-2018) on the structural and functional magnetic resonance imaging (MRI) studies of MDD. Despite the growing number of MRI studies on MDD, reverse inference is not possible as MRI scans cannot be used to aid in the diagnosis or treatment planning of patients with MDD. Hence, researchers must develop "bridges" to overcome the reverse inference fallacy in order to build effective tools for MDD diagnostics. From our findings, we proposed that the "bridges" may be built using multidisciplinary technologies, such as artificial intelligence, multimodality imaging, and nanotheranostics, allowing for the further study of MDD at the biological level. In return, the "bridges" will aid in the development of future diagnostics for MDD and other mental disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.