Evidence map›Paper›PMID 31819007›Full record

ArticleThe Journal of biological chemistry2020

Human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function.

Alex Broussard, Alyssa Florwick, Chelsea Desbiens, Nicole Nischan, Corrina Robertson, Ziqiang Guan, Jennifer J Kohler, Lance Wells, Michael Boyce

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alex BroussardDepartment of Biochemistry, Duke University, Durham, North Carolina 27710.
Alyssa FlorwickDepartment of Biochemistry, Duke University, Durham, North Carolina 27710.
Chelsea DesbiensDepartment of Chemistry, University of Georgia, Athens, Georgia 30602.
Nicole NischanDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Corrina RobertsonDepartment of Biochemistry, Duke University, Durham, North Carolina 27710.
Ziqiang GuanDepartment of Biochemistry, Duke University, Durham, North Carolina 27710.
Jennifer J KohlerDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390.ORCID 0000-0001-5373-3329
Lance WellsDepartment of Chemistry, University of Georgia, Athens, Georgia 30602.
Michael BoyceDepartment of Biochemistry, Duke University, Durham, North Carolina 27710 michael.boyce@duke.edu.ORCID 0000-0002-2729-4876
Duke University · USThe University of Texas Southwestern Medical Center · USUniversity of Georgia · US

Funding

STEROL LIPIDSU54GM069338 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 2003 to 2013
$72.2M
DHDDS and Retinal DegenerationR01EY023666 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WEN, RONG · 2014 to 2018
$2.8M
NEI NIH HHS R01 EY023666NIGMS NIH HHS U54 GM069338
6 · The paper itself

Abstract

Glycan biosynthesis relies on nucleotide sugars (NSs), abundant metabolites that serve as monosaccharide donors for glycosyltransferases.

Indexed as

ApoptosisChromatography, LiquidDeoxy Sugarsfas ReceptorGene Knockout TechniquesGlycolipidsGlycoproteinsGlycosylationHEK293 CellsHeLa CellsHumansMass SpectrometryN-Acetylneuraminic AcidPolysaccharidesReceptors, Cell SurfaceSugarsDeoxy SugarsFAS protein, humanfas ReceptorGlycolipidsGlycoproteinsN-Acetylneuraminic AcidPolysaccharidesReceptors, Cell SurfaceSugarsUDPglucose 4-Epimeraseapoptosiscarbohydrate metabolismCD95 (APO-1/Fas)galactoseglycobiologyglycolipidglycoproteinintegrinnucleoside/nucleotide metabolismUDP-galactose 4′-epimerase (GALE)

Identifiers

PMID31819007
PMCPMC6996900
OpenAlexW2996071510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.