Evidence map›Paper›PMID 31819003›Full record

ArticleThe Journal of biological chemistry2020

Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis.

Joseph Aldahl, Jiaqi Mi, Ariana Pineda, Won Kyung Kim, Adam Olson, Erika Hooker, Yongfeng He, Eun-Jeong Yu, Vien Le, Dong-Hoon Lee and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  9. Review
  10. Wnt/β-Catenin Signaling in Oral Carcinogenesis.International journal of molecular sciences · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joseph AldahlDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Jiaqi MiDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Ariana PinedaDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Won Kyung KimDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Adam OlsonDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Erika HookerDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Yongfeng HeDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Eun-Jeong YuDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Vien LeDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Dong-Hoon LeeDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Joseph GeradtsDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, California 91010-3000.
Zijie SunDepartment of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California 91010-3000. Electronic address: zjsun@coh.org.
City of Hope · USCity Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Roles of the androgen receptor and its co-regulators in prostate tumorigenesisR01CA070297 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2003 to 2025
$5.0M
Wnt responsive stem cells in the prostateR01DK104941 · NIDDK · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2015 to 2024
$3.0M
A New Mechanism for Castration Resistant Prostate CancerR01CA166894 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2015 to 2018
$1.2M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA070297NCI NIH HHS R01 CA166894NIDDK NIH HHS R01 DK104941
6 · The paper itself

Abstract

Co-occurrence of aberrant hepatocyte growth factor (HGF)/MET proto-oncogene receptor tyrosine kinase (MET) and Wnt/β-catenin signaling pathways has been observed in advanced and metastatic prostate cancers. This co-occurrence positively correlates with prostate cancer progression and castration-resistant prostate cancer development. However, the biological consequences of these abnormalities in these disease processes remain largely unknown. Here, we investigated the aberrant activation of HGF/MET and Wnt/β-catenin cascades in prostate tumorigenesis by using a newly generated mouse model in which both murine

Indexed as

Signal TransductionAnimalsbeta CateninCarcinogenesisHepatocyte Growth FactorHumansMaleMice, Inbred C57BLMice, SCIDProstateProstatic NeoplasmsProto-Oncogene MasProto-Oncogene Proteins c-metbeta CateninHepatocyte Growth FactorMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-metbeta-catenin (B-catenin)cell signalinghepatocyte growth factor/scatter factor (HGF/SF)metastasisMET proto-oncogene receptor tyrosine kinase (MET)mouseprostate cancertransgenic micetumorigenesisWnt signaling

Identifiers

PMID31819003
PMCPMC6956540
OpenAlexW2994995322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.