Evidence map›Paper›PMID 31818813›Full record

ArticleAntimicrobial agents and chemotherapy2020

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis.

Sondus Alkhazraji, Teclegiorgis Gebremariam, Abdullah Alqarihi, Yiyou Gu, Zeinab Mamouei, Shakti Singh, Nathan P Wiederhold, Karen J Shaw, Ashraf S Ibrahim

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 87 citations in OpenAlex.

  1. Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Review
  3. Manogepix demonstrates potentAntimicrobial agents and chemotherapy · 2026
    Article
  4. New Perspectives on Antimicrobial Agents: Fosmanogepix.Antimicrobial agents and chemotherapy · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Fungal Meningitis in US Patients Who Received Epidural Anesthesia in Matamoros, Mexico.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  9. MultisystemASM case reports · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Non-JHLT open · 2025
    Review
  14. Antimicrobial agents and chemotherapy · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Fungal lung disease.The European respiratory journal · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sondus Alkhazraji *Division of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
Teclegiorgis Gebremariam *Division of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
Abdullah AlqarihiDivision of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
Yiyou GuDivision of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
Zeinab MamoueiDivision of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
Shakti SinghDivision of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.ORCID 0000-0001-6521-0998
Nathan P WiederholdUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-2225-5122
Karen J ShawAmplyx Pharmaceuticals, Inc., San Diego, California, USA kshaw@amplyx.com ibrahim@labiomed.org.
Ashraf S IbrahimDivision of Infectious Diseases, The Lundquist Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA kshaw@amplyx.com ibrahim@labiomed.org.
UCLA Medical Center · USAmplyx Pharmaceuticals (United States) · USThe University of Texas Health Science Center at San Antonio · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to

Indexed as

Immunocompromised HostAminopyridinesAnimalsAntifungal AgentsBiological AvailabilityBrainDrug Administration ScheduleDrug CombinationsFusariosisFusariumHalf-LifeHumansInvasive Fungal InfectionsIsoxazolesKidneyLung1-aminobenzotriazoleAminopyridinesAntifungal AgentsAPX001ADrug CombinationsIsoxazolesProdrugsTriazolesantifungalantifungal agentsAPX001APX001AfosmanogepixFusariumGwt1infection modelmanogepixmurineScedosporium

Identifiers

PMID31818813
PMCPMC7038288
OpenAlexW2994417763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.