ArticleJournal of affective disorders2020
Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Dietary eating patterns, dairy consumption, and anxiety: A systematic literature review.PloS one · 2023Pooled it
- Article
- Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study.The Journal of international medical research · 2026Article
- Associations between appetite loss and psychopathology as well as gender differences in adolescents with major depressive disorders.BMC psychiatry · 2025Article
- Gut microbiota as a novel target for treating anxiety and depression: from mechanisms to multimodal interventions.Frontiers in microbiology · 2025Review
- Spatial distribution of antioxidant activity in baguette and its modulation of proinflammatory cytokines in RAW264.7 macrophages.NPJ science of food · 2024Article
- Baseline gut microbiota profiles affect treatment response in patients with depression.Frontiers in microbiology · 2024Review
- Association between empirical dietary inflammatory index, odds, and severity of anxiety disorders: A case-control study.Food science & nutrition · 2023Article
- Elevated serum leptin is associated with attenuated reward anticipation in major depressive disorder independent of peripheral C-reactive protein levels.Scientific reports · 2023Article
- The association between a priori dietary patterns and psychological disorders in military personnel.BMC psychiatry · 2023Article
- Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder.Brain, behavior, and immunity · 2021Article
- Association of Dietary Inflammatory Index (DII) and Depressive Disorders.Journal of inflammation research · 2021Review
- Gut Microbiota Changes in Patients With Major Depressive Disorder Treated With Vortioxetine.Frontiers in psychiatry · 2021Article
- Examining Regional Differences of Dietary Inflammatory Index and Its Association with Depression and Depressive Symptoms in Korean Adults.International journal of environmental research and public health · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is the leading cause of years lived with disability; however, little is known about its etiology to inform treatment. For a subset of MDD patients, appetite change and/or bodily inflammation may play a role in exacerbating symptoms. The goal of this study is to examine whether, relative to healthy comparisons (HC), MDD individuals with increased versus decreased appetite symptoms show a differential relationship between diet quality and inflammation.
methodsUnmedicated current MDD (n = 61) varying in appetite change (decrease (MDD-DE): n = 39; increase (MDD-IN): n = 22) and HC (n = 42) completed 24-hour dietary recall and state depression/anxiety measures. Healthy eating and dietary inflammatory indices were calculated from dietary reports. Blood samples measured five inflammation-related biomarkers. Analyses investigated between- and within-group differences in the Healthy Eating Index (HEI), the Dietary Inflammatory Index (DII), inflammation-related blood biomarkers, and symptom severity.
resultsWhile both MDD-DE and MDD-IN exhibited lower HEI scores than HC, only MDD-IN showed higher plasma interleukin-1 receptor antagonist (IL-1RA) and interleukin-6 (IL-6) levels than HC. In contrast, MDD-DE exhibited higher DII scores than MDD-IN and HC. Within MDD-DE, greater symptom severity was associated with lower HEI and higher DII. LIMITATIONS: Modest sample sizes and the cross-sectional study design limited power to detect within-MDD effects.
conclusionsAlthough MDD, regardless of appetite change, is linked to poorer dietary quality, depression severity was related to dietary characteristics only in subjects who reported appetite loss. Thus, increasing the quality of dietary intake could be a treatment target for some individuals with depression.
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