ReviewTrends in endocrinology and metabolism: TEM2020
Impacts of Caffeine during Pregnancy.
Review in Trends in endocrinology and metabolism: TEM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies.BMC public health · 2024Pooled it
- The association between antenatal coffee consumption and preeclampsia: a systematic review and meta-analysis.Environmental health and preventive medicine · 2024Pooled it
- The association between caffeine exposure during pregnancy and risk of gestational hypertension/preeclampsia: A meta-analysis and systematical review.The journal of obstetrics and gynaecology research · 2022Pooled it
- Glucose Co-Treatment Modulates Caffeine-Induced Transcriptomic Alterations During Embryogenesis in Zebrafish (Biology · 2026Article
- Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health.Hereditas · 2026Review
- Periconceptual Caffeine Intake and Adverse Pregnancy Outcomes: Results From the nuMoM2b Cohort.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Maternal nutritional imbalance during pregnancy and the development of fetal-origin cardiovascular diseases.Frontiers in nutrition · 2026Review
- Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR-1224 Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pregnancy and Caffeine Metabolism: Updated Insights and Implications for Maternal-Fetal Health.Nutrients · 2025Review
- Elucidation of the effects of caffeine consumption on estrous cycle, hematology, and lipid profile of female Wistar rats.Scientific reports · 2025Article
- Caffeine and cardiovascular aging: exploring sex-specific impacts on risk and arrhythmias.Journal of geriatric cardiology : JGC · 2025Article
- Article
- Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation.Scientific reports · 2025Article
- The Fetal Effect of Maternal Caffeine Consumption During Pregnancy-A Review.Biomedicines · 2025Review
- Factors associated with the dietary total antioxidant capacity of pregnant Brazilian women.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Article
- Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.Archives of pharmacal research · 2025Review
- Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2024Review
- Sperm miR-142-3p Reprogramming Mediates Paternal Pre-Pregnancy Caffeine Exposure-Induced Non-Alcoholic Steatohepatitis in Male Offspring Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review.Life (Basel, Switzerland) · 2024Review
- Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort.Archives of gynecology and obstetrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Epidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure. Recent animal studies with physiologically relevant dosages have begun to dissect adverse effects of caffeine during pregnancy with respect to oviduct contractility, embryo development, uterine receptivity, and placentation that jointly contribute to pregnancy complications. Interestingly, caffeine's effects are highly variable between individual animals under well-controlled experimental settings, suggesting the possibility of epigenetic regulation of these phenotypes, in addition to genetic variants. Moreover, caffeine exposure during sensitive windows of pregnancy may induce epigenetic changes in the developing fetus or even the germ cells to cause adult-onset diseases in subsequent generations. We discuss these research frontiers in light of emerging data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.