Evidence map›Paper›PMID 31818266›Full record

ArticleBMC nephrology2019

Protocol for a prospective, cluster randomized trial to evaluate routine and deferred dialysis initiation (RADDI) in Chinese population.

Xinju Zhao, Pei Wang, Lining Wang, Xiaonong Chen, Wen Huang, Yonghui Mao, Rihong Hu, Xiaohong Cheng, Caili Wang, Li Wang and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02423655 (A Randomized, Controlled Trial to Evaluate Routine and Deferred Dialysis Initiation in Chinese Population), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02423655 naunknown statusnot on this map

A Randomized, Controlled Trial to Evaluate Routine and Deferred Dialysis Initiation in Chinese Population

TypeinterventionalSponsorPeking University People's HospitalRan2015 to 2020Enrolled1,049ConditionsChronic Kidney DiseaseArmsAlgorithm for deferred dialysis intervention, Algorithm for routine dialysis intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Xinju ZhaoDepartment of Nephrology, Peking University People's Hospital, Beijing, China.
Pei WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lining WangDepartment of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xiaonong ChenDepartment of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Wen HuangDepartment of Nephrology, Beijing Tongren Hospital Capital Medical University, Beijing, China.
Yonghui MaoDepartment of Nephrology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Rihong HuDepartment of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China.
Xiaohong ChengDepartment of Nephrology, Shaanxi Hospital of Traditional Chinese Medicine, Shaanxi, China.
Caili WangDepartment of Nephrology, The First Affiliated Hospital of Baotou Medical College, Baotou, China.
Li WangDepartment of Nephrology, Sichuan Academy of Medical Sciences, Chengdu, China.
Ping ZhangKidney disease center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Detian LiDepartment of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.
Yuzhu WangDepartment of Nephrology, Beijing Haidian Hospital (Beijing Haidian Section of Peking University Third Hospital), Beijing, China.
Wenling YeDepartment of Nephrology, Peking Union Medical College Hospital, Beijing, China.
Yuqing ChenRenal Division, Peking University First Hospital, Beijing, China.
Qiang JiaDepartment of Nephrology, Xuanwu Hospital Capital Medical University, Beijing, China.
Xiaoyan YanPeking University Clinical Research Institute, Beijing, China.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, Beijing, China. zuoli@bjmu.edu.cn.
Peking University · CNCapital Medical University · CNChina Medical University · CNBaotou Medical College · CNBeijing Haidian Hospital · CNBeijing Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNFirst Hospital of China Medical University · CNHangzhou Hospital of Traditional Chinese Medicine · CNPeking Union Medical College Hospital · CNPeking University People's Hospital · CNRuijin Hospital · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe timing of when to initiate dialysis for progressive chronic kidney disease (CKD) patients has not been well established. There has been a strong trend for early dialysis initiation for these patients over the past decades. However, the perceived survival advantage of early dialysis has been questioned by a series of recent observational studies. The only randomized controlled trial (RCT) research on this issue found the all-cause mortality, comorbidities, and quality of life showed no difference between early and late dialysis starters. To better understand optimal timing for dialysis initiation, our research will evaluate the efficacy and safety of deferred dialysis initiation in a large Chinese population.

methodsThe trial adopts a multicenter, cluster randomized, single-blind (outcomes assessor), and endpoint-driven design. Eligible participants are 18-80 years old, in stable CKD stages 4-5 (eGFR > 7 ml/min /1.73 m DISCUSSION: This study protocol represents a large, cluster randomized study evaluating deferred and routine dialysis intervention for an advanced CKD population. The reference eGFR to initiate dialysis for both treatment groups is targeted at less than 7 ml/min/1.73m

trial registrationThe trial has been approved by ClinicalTrials.gov (Trial registration ID NCT02423655). The date of registration was April 22, 2015.

Indexed as

Population SurveillanceAdolescentAdultAgedAged, 80 and overChinaCluster AnalysisFemaleFollow-Up StudiesHumansMaleMiddle AgedMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicRenal Dialysis

Identifiers

PMID31818266
PMCPMC6902500
OpenAlexW2993951522

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.