Evidence map›Paper›PMID 31818211›Full record

Observational studyJournal of the American Heart Association2019

Association of High-Density Lipoprotein Particles and High-Density Lipoprotein Apolipoprotein C-III Content With Cardiovascular Disease Risk According to Kidney Function: The Multi-Ethnic Study of Atherosclerosis.

Julio A Lamprea-Montealegre, Robyn L McClelland, James D Otvos, Samia Mora, Manja Koch, Majken K Jensen, Ian H de Boer

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Julio A Lamprea-MontealegreDivision of Cardiology Department of Medicine Kidney Research Institute University of Washington Seattle WA.
Robyn L McClellandDepartment of Biostatistics University of Washington Seattle WA.
James D OtvosLaboratory Corporation of America Holdings Morrisville NC.
Samia MoraDivisions of Cardiovascular and Preventive Medicine Center for Lipid Metabolomics Brigham and Women's Hospital and Harvard Medical School Harvard University Boston MA.
Manja KochHarvard T.H. Chan School of Public Health Harvard University Boston MA.
Majken K JensenHarvard T.H. Chan School of Public Health Harvard University Boston MA.
Ian H de BoerDivision of Nephrology Department of Medicine Department of Epidemiology Kidney Research Institute University of Washington Seattle WA.
Harvard University · USUniversity of Washington · USLabCorp (United States) · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420
6 · The paper itself

Abstract

Background Chronic kidney disease is associated with structural and compositional abnormalities in high-density lipoprotein particles (HDLp). We examined associations of HDLp size, particle subfractions, and apolipoprotein C-III content with incident cardiovascular disease (CVD) events across categories of estimated glomerular filtration rate (eGFR). Methods and Results Analyses included 6699 participants in MESA (Multi-Ethnic Study of Atherosclerosis) with measurements of HDLp and 5723 participants with measurements of HDL apolipoprotein C-III. Cox-regression methods were used to evaluate associations between HDLp and apolipoproteins with CVD events. Larger HDLp size was associated with lower CVD risk in participants with lower eGFR: hazard ratio (95% CI) per SD higher mean HDL size was 1.00 (0.90-1.11) in eGFR ≥60 mL/min per 1.73 m

Indexed as

Glomerular Filtration RateAgedApolipoprotein C-IIIAtherosclerosisCardiovascular DiseasesFemaleHumansLipoproteins, HDLMaleMiddle AgedParticle SizeProspective StudiesRacial GroupsRisk FactorsApolipoprotein C-IIILipoproteins, HDLapolipoproteincardiovascular diseasechronic kidney diseasehigh‐density lipoprotein particle size

Identifiers

PMID31818211
PMCPMC6951074
OpenAlexW2996350970

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.