Evidence map›Paper›PMID 31818188›Full record

ArticleEpigenetics2020

Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards.

Yu Jiang, Jinfeng Wei, Hongmei Zhang, Susan Ewart, Faisal I Rezwan, John W Holloway, Hasan Arshad, Wilfried Karmaus

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Shared DNA methylation signatures in childhood allergy: The MeDALL study.The Journal of allergy and clinical immunology · 2021
    Pooled it
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  8. Newborn DNA methylation and asthma acquisition across adolescence and early adulthood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yu JiangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.ORCID 0000-0002-2437-9268
Jinfeng WeiCollege of Arts and Sciences, Maryville University, St. Louis, MO, USA.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Susan EwartDepartment of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-6462-7043
Faisal I RezwanHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-9998-0464
Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
University of Memphis · USUniversity of Southampton · GBDavid Hide Asthma and Allergy Research Centre · GBMaryville University · USMichigan State University · US

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Effect of Prenatal Compounds on Adult Lung Function via Neonatal DNA MethylationR01HL132321 · NHLBI · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2016 to 2020
$3.2M
Epigenetic characterization of pubertal transitionsR03HD092776 · NICHD · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2017 to 2018
$133k
NHLBI NIH HHS R01 HL132321NIAID NIH HHS R01 AI121226NICHD NIH HHS R03 HD092776
6 · The paper itself

Abstract

DNA methylation (DNAm) in blood (umbilical cord blood and capillary blood collected after birth on Guthrie cards) during the perinatal period is being increasingly studied with the aim of identifying epigenetic markers of in utero environmental exposures or later disease development. However, the comparability in DNAm between these two sources is unknown. To this end, DNAm from the cord blood and capillary blood of 34 subjects in the Isle of Wight 3

Indexed as

DNA MethylationEpigenomeAdultCpG IslandsFemaleFetal BloodGenetic TestingHumansInfant, NewbornMaleNeonatal ScreeningPregnancyPrenatal Exposure Delayed EffectsSmokingcord bloodDNA methylationGuthrie cardsIsle of Wight

Identifiers

PMID31818188
PMCPMC7188390
OpenAlexW2996570328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.