ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2020
Protocol for Clozapine Rechallenge in a Case of Clozapine-Induced Myocarditis.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Multidisciplinary consensus on prevention, screening and monitoring of clozapine-associated myocarditis and clozapine rechallenge after myocarditis.The British journal of psychiatry : the journal of mental science · 2026Pooled it
- The adverse effects of clozapine on blood markers and electrocardiographic findings in patients with schizophrenia.BioMedicine · 2026Article
- Reliability of tachycardia as an early warning sign in acute clozapine-induced cardiac inflammation: Protocol for a systematic review.PloS one · 2026Article
- Clozapine rechallenge after clozapine-induced myocarditis: A case report to validate a previously published protocol.The mental health clinician · 2025Article
- Review
- Clozapine-induced myocarditis and subsequent rechallenge: a narrative literature review and case report.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2023Article
- Myocarditis in patients on long-term antipsychotics -mechanism, management and recent updates.Heliyon · 2023Review
- Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia.Therapeutic advances in psychopharmacology · 2023Review
- Successful rechallenge with clozapine after discontinuation due to drug-induced pneumonia: A case report.PCN reports : psychiatry and clinical neurosciences · 2022Article
- Successful clozapine rechallenge after myopericarditis: a case report.International clinical psychopharmacology · 2022Article
- A Slow, Cautious, and Successful Clozapine Rechallenge After Myocarditis.The primary care companion for CNS disorders · 2022Article
- Re: Protocol for Clozapine Rechallenge in a Case of Clozapine-induced Myocarditis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report.BMC psychiatry · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProtocol for clozapine rechallenge in patients with a history of clozapine-induced myocarditis.
methodClozapine-related cardiovascular adverse effects including myocarditis and cardiomyopathy have limited its widespread use in treatment-resistant schizophrenia. Here, we present a case of clozapine-induced myocarditis and successful cautious rechallenge. Ms. AA, a young female patient with severe psychosis developed myocarditis during her initial clozapine titration phase, which was thus discontinued. Subsequent response to other medications was poor, and she remained significantly disabled. We reviewed blood-based biomarkers identified during the emergence of her index episode of myocarditis and developed a successful clozapine rechallenge protocol, based on careful monitoring of changes in these indices and a very slow clozapine re-titration. RESULTS AND
conclusionsThis protocol may have utility in the management of patients with a history of clozapine-induced myocarditis.
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Registered trials
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