Evidence map›Paper›PMID 31818017›Full record

ArticleMolecules (Basel, Switzerland)2019

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line.

Yollanda E M Franco, Marcia Y Okubo, Adriana D Torre, Paula P Paiva, Marcela N Rosa, Viviane A O Silva, Rui M Reis, Ana L T G Ruiz, Paulo M Imamura, João E de Carvalho and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Labdane Diterpenoids fromDiseases (Basel, Switzerland) · 2025
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  9. Antitumoral Properties of Natural Products.Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yollanda E M FrancoResearch Laboratory in Molecular Pharmacology of Bioactive Compounds. São Francisco University, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0003-4598-8000
Marcia Y OkuboChemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas-UNICAMP, Paulínia 13148-218, SP, Brazil.
Adriana D TorreChemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas-UNICAMP, Paulínia 13148-218, SP, Brazil.
Paula P PaivaChemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas-UNICAMP, Paulínia 13148-218, SP, Brazil.ORCID 0000-0001-5282-1896
Marcela N RosaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14.784-400, SP, Brazil.ORCID 0000-0003-2896-1578
Viviane A O SilvaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14.784-400, SP, Brazil.ORCID 0000-0001-5919-5242
Rui M ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14.784-400, SP, Brazil.ORCID 0000-0002-9639-7940
Ana L T G RuizPosgraduate program in dentistry, Piracicaba Dental School, University of Campinas, Piracicaba 13 414-903, SP, Brazil.ORCID 0000-0002-0844-8702
Paulo M ImamuraInstitute of Chemistry, University of Campinas-UNICAMP, P.O. Box 6154, Campinas 13083-970, SP, Brazil.
João E de CarvalhoPosgraduate program in dentistry, Piracicaba Dental School, University of Campinas, Piracicaba 13 414-903, SP, Brazil.
Giovanna B LongatoResearch Laboratory in Molecular Pharmacology of Bioactive Compounds. São Francisco University, Bragança Paulista 12916-900, SP, Brazil.ORCID 0000-0001-5828-8957
Universidade Estadual de Campinas (UNICAMP) · BRHospital de Câncer de Barretos · BRUniversidade São Francisco · BR

Funding

Financiadora de Estudos e Projetos MCTI/ FINEP/MS/SCTIE/DECIT-01/2013 - FPXII-BIOPLATFundação de Amparo à Pesquisa do Estado de São Paulo 2014/06636-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/06137-6
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most frequent and highest-grade brain tumor in adults. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. The development of more efficient drugs without noticeable side effects is urgent. Coronarin D is a diterpene obtained from the rhizome extract of

Indexed as

ApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalDiterpenesGlioblastomaHumansPhosphorylationReactive Oxygen SpeciesZingiberaceaecoronarin DDiterpenesReactive Oxygen Speciesapoptosiscell cycle arrestcoronarin Dglioblastomanatural products

Identifiers

PMID31818017
PMCPMC6943529
OpenAlexW2991719625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.