ArticlePharmaceutics2019
Investigation of Silicone-Containing Semisolid in Situ Film-Forming Systems Using QbD Tools.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Dihydromyricetin-LoadedPharmaceutics · 2026Article
- PLGA-Based In Situ-Forming Implants, a Quality by Design Perspective.Pharmaceutics · 2026Review
- Development,Drug delivery · 2025Article
- An Overview of Film-Forming Emulsions for Dermal and Transdermal Drug Delivery.AAPS PharmSciTech · 2024Review
- Quality by Design Perspective for Designing Foam-based Formulation: Current State of Art.Current pharmaceutical design · 2024Review
- Quality by Design Assisted Optimization and Risk Assessment of Black Cohosh Loaded Ethosomal Gel for Menopause: Investigating Different Formulation and Process Variables.Pharmaceutics · 2023Article
- Chemical Profile and Biological Effects of an Herbal Mixture for the Development of an Oil-in-Water Cream.Plants (Basel, Switzerland) · 2023Article
- Coupling AFM, DSC and FT-IR towards Elucidation of Film-Forming Systems Transformation to Dermal Films: A Betamethasone Dipropionate Case Study.International journal of molecular sciences · 2022Article
- Silsesquioxanes in the Cosmetics Industry-Applications and Perspectives.Materials (Basel, Switzerland) · 2022Review
- Article
- QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia.Drug design, development and therapy · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The aim of our research work was to develop dermally applicable, semisolid film-forming systems (FFSs) containing silicones, which form a film on the skin in situ, with suitable mechanical properties for skin application. FFSs were developed and investigated by means of the Quality by Design (QbD) methodology. With this QbD approach, the initial risk assessment defines the critical quality attributes (CQAs), the critical material attributes (CMAs) and the critical process parameters (CPPs) to ensure the required quality. Different semisolid systems were formed with or without silicones. During the initial risk assessment, three CQAs, namely skin adhesion, film flexibility and burst strength, were found to be critical attributes, while film appearance, film integrity and the drying time of the semisolid system, were found to be medium attributes. These parameters were investigated. The initial risk assessment also showed that there are three high CMAs: the type of silicones, film-forming excipients, drying excipients, and that there was one medium CMA: viscosity-enhancing excipients. Based on our results, the silicone content had a great effect on the film-forming systems. Different silicones affected the mechanical properties of the films in varying ways, decreased the drying time and showed promising results regarding the drying mechanism.
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Registered trials
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