Evidence map›Paper›PMID 31817859›Full record

ArticleNutrients2019

Plasma Phospholipid Fatty Acids,

Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M Mason, Stephen Burgess, Susanna Larsson

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  5. Frontiers in nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0001-5055-5627
Magnus BäckDepartment of Medicine, Center for Molecular Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden.ORCID 0000-0003-0853-5141
Maria BruzeliusCoagulation Unit, Department of Hematology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Amy M MasonDepartment of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK.ORCID 0000-0002-8019-0777
Stephen BurgessDepartment of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK.
Susanna LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0003-0118-0341
Karolinska University Hospital · SEUniversity of Cambridge · GBUppsala University · SE

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Forskningsrådet om Hälsa, Arbetsliv och Välfärd 2018-00123Medical Research Council MC_UU_00002/7Vetenskapsrådet 2019-00977Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA levels and 15 CVDs. Summary-level data from the CARDIoGRAMplusC4D, MEGASTROKE, and Atrial Fibrillation consortia and UK Biobank were used. Sixteen single-nucleotide polymorphisms (SNPs) associated with ten plasma FAs were used as instrumental variables. SNPs in or close to the

Indexed as

Allelesalpha-Linolenic AcidArachidonic AcidCardiovascular DiseasesData AnalysisDelta-5 Fatty Acid DesaturaseFatty Acid DesaturasesFatty AcidsGenetic Predisposition to DiseaseHumansLinoleic AcidMendelian Randomization AnalysisOdds RatioOleic AcidPhospholipidsPolymorphism, Single Nucleotidealpha-Linolenic AcidArachidonic AcidDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acid DesaturasesFatty AcidsLinoleic AcidOleic AcidPhospholipidsStearic Acids?5-desaturasecardiovascular diseasedietFADSfatty acidsMendelian randomisation

Identifiers

PMID31817859
PMCPMC6950527
OpenAlexW2992904911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.