Evidence map›Paper›PMID 31817853›Full record

ArticleInternational journal of molecular sciences2019

SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric

Valentina Serafin, Elena Porcù, Giuliana Cortese, Elena Mariotto, Giulia Veltri, Silvia Bresolin, Giuseppe Basso, Benedetta Accordi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Novel Biomarkers and Molecular Targets in ALL.Current hematologic malignancy reports · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valentina SerafinIstituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Elena PorcùLaboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Giuliana CorteseDepartment of Statistical Sciences, University of Padova, 35121 Padova, Italy.
Elena MariottoLaboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-3960-8561
Giulia VeltriLaboratory of Pediatric Oncohematology, Department of Woman's and Child's Health, University of Padova, 35128 Padova, Italy.
Silvia BresolinIstituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Giuseppe BassoIstituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.
Benedetta AccordiIstituto di Ricerca Pediatrica Città della Speranza, 35127 Padova, Italy.ORCID 0000-0002-2359-1056
University of Padua · ITCittà della Speranza Foundation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of the chromosomal rearrangement t(12;21)(

Indexed as

AminopyridinesCell ProliferationChildCore Binding Factor Alpha 2 SubunitCyclohexylaminesDrug Resistance, NeoplasmETS Translocation Variant 6 ProteinHumansIndazolesMorpholinesNeoplasm Recurrence, LocalOncogene Proteins, FusionOxazinesPrecursor B-Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsPyrazines2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo(1,2-a)pyrazin-8-amineAminopyridinesCore Binding Factor Alpha 2 SubunitCyclohexylaminesETS Translocation Variant 6 ProteinfostamatinibIndazolesMorpholinesOncogene Proteins, FusionOxazinesProtein Kinase InhibitorsPyrazinesPyridinesPyrimidinesSyk KinaseSYK protein, humanTEL-AML1 fusion proteinentospletinibleukemiarelapseSYK

Identifiers

PMID31817853
PMCPMC6940898
OpenAlexW2992749177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.