ArticleNutrients2019
Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.Clinical epigenetics · 2022Pooled it
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial.Blood advances · 2024Trial
- Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4-year-old children.Maternal & child nutrition · 2024Trial
- Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study.Nutrition journal · 2025Article
- The Individual and Combined Effects of Prenatal Micronutrient Supplementations on Neurobehavioral Developmental Disorders in Preschool Children.Children (Basel, Switzerland) · 2025Article
- Effects of prenatal iron deficiency on neurological development and related disorders in offspring.Frontiers in nutrition · 2025Review
- Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity.International journal of medical sciences · 2025Article
- The effects of early childhood probiotic intake on the association between prenatal micronutrient supplementation and neurobehavioral development in preschool children: a four-way decomposition analysis.Frontiers in nutrition · 2025Article
- Iron and Pregnancy.Advances in experimental medicine and biology · 2025Review
- Early life stress and iron metabolism in developmental psychoneuroimmunology.Brain, behavior, & immunity - health · 2024Article
- Association between Dietary Patterns during Pregnancy and Children's Neurodevelopment: A Birth Cohort Study.Nutrients · 2024Article
- Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.Nutrients · 2024Review
- Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.Annual review of nutrition · 2023Review
- Association between the Use of Folic Acid Supplements during Pregnancy and Children's Cognitive Function at 7-9 Years of Age in the INMA Cohort Study.International journal of environmental research and public health · 2022Article
- Maternal early-pregnancy ferritin and offspring neurodevelopment: A prospective cohort study from gestation to school age.Paediatric and perinatal epidemiology · 2022Article
- Ethnic differences in adverse iron status in early pregnancy: a cross-sectional population-based study.Journal of nutritional science · 2022Article
- Relationship between patient ethnicity and prevalence of anemia during pregnancy and the puerperium period and compliance with healthcare recommendations - implications for targeted health policy.Israel journal of health policy research · 2020Article
- Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study.International journal of environmental research and public health · 2020Article
- Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.