Evidence map›Paper›PMID 31817781›Full record

ArticlePharmaceutics2019

Monitoring the Fate of Orally Administered PLGA Nanoformulation for Local Delivery of Therapeutic Drugs.

Lucia Morelli, Sara Gimondi, Marta Sevieri, Lucia Salvioni, Maria Guizzetti, Barbara Colzani, Luca Palugan, Anastasia Foppoli, Laura Talamini, Lavinia Morosi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Article
  6. Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery.International journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Lucia MorelliNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.ORCID 0000-0003-0329-3841
Sara GimondiIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.ORCID 0000-0002-6660-0477
Marta SevieriIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Lucia SalvioniNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Maria GuizzettiNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Barbara ColzaniNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
Luca PaluganDipartimento di Scienze Farmaceutiche, Università di Milano, Via Giuseppe Colombo 71, 20133 Milano, Italy.
Anastasia FoppoliDipartimento di Scienze Farmaceutiche, Università di Milano, Via Giuseppe Colombo 71, 20133 Milano, Italy.
Laura TalaminiIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Lavinia MorosiIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Massimo ZucchettiIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.ORCID 0000-0002-5427-052X
Martina Bruna ViolattoIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Luca RussoIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Mario SalmonaIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Davide ProsperiNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.ORCID 0000-0003-4577-9575
Miriam ColomboNanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.ORCID 0000-0003-3428-5668
Paolo BiginiIRCCS Mario Negri Institute for Pharmacological Research, Via Mario Negri 2, 20157 Milano, Italy.
Mario Negri Institute for Pharmacological Research · ITUniversity of Milano-Bicocca · ITUniversity of Milan · ITIstituti Clinici Scientifici Maugeri · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza-2017" to University of Milano Bicocca, Department of Biotechnology and Biosciences,Regione Lombardia Direzione Generale Ricerca, Innovazione, Università, Export e InternazionalizzazioneUnimib Academic Funding
6 · The paper itself

Abstract

One of the goals of the pharmaceutical sciences is the amelioration of targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range of human disorders. In this study, we investigated the possibility of improving the selective release of the anti-cancer drug paclitaxel (PTX) in the gastro-intestinal tract by encapsulating it into the biodegradable nanoparticles made by FDA-approved poly(lactic-

Indexed as

gastrointestinal tractin vivo imagingnanomedicinepaclitaxelPLGA-NPs

Identifiers

PMID31817781
PMCPMC6955864
OpenAlexW2992712686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.