ReviewNutrients2019
Neuroprotective Effects of Choline and Other Methyl Donors.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Dietary choline intake and incident dementia in middle-aged and older adults: a prospective cohort study and dose-response meta-analysis.Nutrition journal · 2026Pooled it
- Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.Nutrients · 2020Pooled it
- Choline enhances elicited imitation memory performance in preschool children with prenatal alcohol exposure: a cumulative report of 3 randomized controlled trials.The American journal of clinical nutrition · 2025Trial
- Usual intake of one-carbon metabolism nutrients in a young adult population aged 19-30 years: a cross-sectional study.Journal of nutritional science · 2023Trial
- Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.Journal of neurodevelopmental disorders · 2022Trial
- Determining the metabolic profile measured using ultra-high pressure liquid chromatography associated with Beta Amyloid burden in the brain in individuals with mild cognitive impairment.Research square · 2026Article
- Choline and Its Companions: Inter-Related Roles of Choline and B Vitamins in Fetal Development and Offspring Health.Nutrients · 2026Review
- The role of choline in neurodevelopment.Pediatric research · 2026Review
- Association between methyl donor nutrients intake with sleep duration, sleep quality and biomarkers of oxidative stress and inflammation among adults.Nutrition journal · 2026Article
- Association of dietary choline intake in late pregnancy with the early neurobehavioral development of offspring.European journal of nutrition · 2026Article
- Panoramic Research onInternational journal of molecular sciences · 2025Review
- Article
- The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study.Nutrition journal · 2025Article
- Metabolomic analysis reveals an important role of sphingosine 1-phosphate in the development of HFMD due to EV-A71 infection.Antimicrobial agents and chemotherapy · 2025Article
- Maternal effects in the model system Daphnia: the ecological past meets the epigenetic future.Heredity · 2025Review
- Associations of dietary choline intake and kidney function with hyperuricemia in Chinese children and adolescents: a cross-sectional study.EClinicalMedicine · 2025Article
- Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis.International journal of molecular sciences · 2025Article
- Untargeted metabolomic analysis of dietary rumen-protected choline supplementation in fattening lambs.Frontiers in veterinary science · 2025Article
- Protective Role of Electroacupuncture Against Cognitive Impairment in Neurological Diseases.Current neuropharmacology · 2025Review
- The Importance of Gut Microbiota on Choline Metabolism in Neurodegenerative Diseases.Biomolecules · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that physical and mental health are influenced by an intricate interaction between genes and environment. Environmental factors have been shown to modulate neuronal gene expression and function by epigenetic mechanisms. Exposure to these factors including nutrients during sensitive periods of life could program brain development and have long-lasting effects on mental health. Studies have shown that early nutritional intervention that includes methyl-donors improves cognitive functions throughout life. Choline is a micronutrient and a methyl donor that is required for normal brain growth and development. It plays a pivotal role in maintaining structural and functional integrity of cellular membranes. It also regulates cholinergic signaling in the brain via the synthesis of acetylcholine. Via its metabolites, it participates in pathways that regulate methylation of genes related to memory and cognitive functions at different stages of development. Choline-related functions have been dysregulated in some neurodegenerative diseases suggesting choline role in influencing mental health across the lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.